Single-Port RAS Using Da Vinci SP Surgical System for UTUC Patients

Launched by NATIONAL TAIWAN UNIVERSITY HOSPITAL · May 15, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a new way to perform surgery for patients with upper tract urothelial cancer, which is a type of cancer affecting the kidneys and the tubes that connect them to the bladder. The study will use a special robotic system called the Da Vinci SP to carry out a surgery called radical nephroureterectomy, which involves removing the affected kidney and part of the bladder. Researchers want to find out how patients feel after the surgery and whether this new method is effective and safe.

To join the trial, participants need to be at least 20 years old and have been diagnosed with upper tract urothelial cancer. They should be in generally good health without serious other illnesses and able to follow the study's guidelines. Unfortunately, those with certain conditions, like advanced bladder cancer, significant weight issues, or severe heart or lung problems, won't be eligible. If you qualify and choose to participate, you can expect to receive detailed information about the surgery, its potential benefits and risks, and what to expect during recovery. This study aims to improve surgical options for patients and help researchers understand how this robotic surgery impacts recovery and quality of life.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 20 years or more
• • Histologically or cytologically diagnosed upper tract urothelial cancer
• • Fitting indications of radical nephroureterectomy and ipsilateral bladder cuff resection, and deemed feasible for robotic surgery
• • ASA physical status classification 1-2 and adequate organ function
• • Patients willing and able to comply with study protocol requirements and follow-up
• • With informed consent
• Exclusion Criteria:
• • Synchronous bladder cancer
• • Distant metastasis of cancer
• • BMI ≥30 or BMI \<18.5
• • Unable to tolerate lateral decubitus or Trendelenburg position (relative contra-indication)
• • Severe adhesion due to prior abdominopelvic surgery (relative contra-indication)
• • Previous radiation treatment to the pelvic area
• • Active infectious disease
• • Severe concomitant illness that drastically shortens life expectancy or increases risk of therapeutic interventions, such as: severe heart disease (NYHA functional class III-IV) or severe lung disease (GOLD Group C-D)
• • Cannot follow trial-required procedures
• • Concomitant systemic or pelvic disease that increases the risk of surgery
• • Long-term use of anti-coagulant(s)
• • Patients with coagulopathy
• • Emergency surgery