Dexamethasone Palmitate for PONV After Craniotomy

Launched by BEIJING TIANTAN HOSPITAL · May 21, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a medication called dexamethasone palmitate to see if it can help prevent nausea and vomiting after brain surgery (known as craniotomy). Even though dexamethasone is commonly used to prevent these symptoms, some patients still experience nausea and vomiting afterward. Dexamethasone palmitate may work better because it lasts longer and has fewer side effects compared to regular dexamethasone.

To participate in this trial, you need to be between 18 and 65 years old and planned for elective brain surgery under general anesthesia. However, you cannot join if you have certain medical conditions, such as severe heart or liver problems, or if you are allergic to dexamethasone. If you enroll, you will receive the study medication before your surgery, and the trial will monitor how well it works in preventing nausea and vomiting afterward. This research is important as it may lead to more effective treatments for patients undergoing brain surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged 18 to 65 years;
• • Providing written informed consent;
• • Perform elective craniotomy undergoing general anesthesia.
• Exclusion Criteria:
• • Known to be allergic to dexamethasone;
• • Any systemic glucocorticoids within 3 months before trial entry;
• • History of severe heart disease, liver/kidney failure, or systemic rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, et al);
• • Cognitive impairment or severe mental illness;
• • Uncontrolled diabetes or infectious diseases;
• • Pregnancy or breastfeeding.