Multifaceted Intervention to Restore Resilience and Overcome Risk

Launched by ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · May 16, 2025

Keywords

ClinConnect Summary

The MIRROR study is a clinical trial designed to help female veterans who have experienced military sexual trauma (MST) or intimate partner violence (IPV). The trial will compare two different programs aimed at improving how these women manage their emotions and reduce symptoms of post-traumatic stress disorder (PTSD), especially when they also have a history of brain injury. This study is not yet recruiting participants but will focus on women aged 18 and older who can speak English and have experienced MST or IPV, have a history of brain injury, and show some symptoms of PTSD.

To be eligible for this study, participants must be willing to consent and meet certain criteria, such as having experienced IPV or MST and reporting difficulties in managing their emotions. However, those at high risk for suicide or with severe mental health issues will not be able to participate. Women who qualify for this study can expect to engage in activities that aim to enhance their emotional well-being and potentially improve their PTSD symptoms in a supportive environment. This trial is a valuable opportunity for eligible veterans to receive help and support for their experiences.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Able to consent as determined by UBACC, are English-speaking FVets who are 18+ years old
• • Screen positive for exposure to IPV and/or MST using the VA Intimate Partner Violence Assistance Program (VA IPVAP) and MST Screening Protocol,
• • Have a history of at least one BI assessed using the BISQ+IPV,
• • Sub-threshold PTSD (operationalized as a total score of \>33 on the PTSD Checklist Diagnostic and Statistical Manual of Mental Disorders-5 (PCL-5),
• • Report deficits in Emotion Regulation (operationalized as a score of 0.5 SD above published means on the DERS).
• Exclusion Criteria:
• • FVets at high risk for suicide (respond yes to items 3, 4, 5, or 8 on the Columbia Suicide Severity Rating Scale \[C-SSRS\]),
• • Observable active psychosis (e.g., auditory hallucinations, grandiose delusions),
• • Those determined to have problematic substance use (score \> 27 on the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) will be referred to substance use dependence programs for concurrent treatment. The PI and Co-Is will collaborate with the substance use dependence program to determine continued participation.