Comparison of G-CSF & Antibiotics Versus Antibiotics Alone in Resolution of Febrile Neutropenia

Launched by KING EDWARD MEDICAL UNIVERSITY · May 23, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the best way to help children with cancer who develop a condition called febrile neutropenia, which is a fever combined with low levels of white blood cells due to chemotherapy. The researchers want to compare two treatment options: one group will receive a type of medicine called G-CSF (which helps boost the immune system) along with antibiotics, while the other group will only receive antibiotics. The goal is to determine which treatment works better for these children.

To be eligible for the trial, children must be between the ages of 1 and 16, have been diagnosed with cancer, and be undergoing chemotherapy. However, children who have a fever for reasons other than low white blood cell counts or who have already received certain treatments before arriving at the hospital will not be included. If your child participates, they will be monitored closely throughout the study to see how well their condition improves with the different treatments. This trial is important as it aims to find the most effective way to support young patients during a challenging time in their treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 1-16 years
• • any Gender
• • Febrile neutropenia
• • diagnosed case of solid or hematological malignancy
• • taking chemotherapy
• Exclusion Criteria:
• • Non-neutropenic fever
• • already received G-CSF or antibiotics before presenting to hospital
• • any other cause of neutropenia