Study of Human Ocular Hemodynamics by Holography Dopple

Launched by CENTRE HOSPITALIER NATIONAL D'OPHTALMOLOGIE DES QUINZE-VINGTS · May 16, 2025

Keywords

ClinConnect Summary

This clinical trial is designed to study blood flow in the eyes using a special imaging technique called Holography Dopple. It's focused on patients with conditions like glaucoma and those with retinal vascular disorders, which can affect vision. The goal is to better understand how these conditions impact eye circulation. The trial will take place at multiple locations and will include both patients and healthy volunteers aged 18 to 74.

To participate, individuals must be generally healthy or have specific eye conditions that are being monitored. For patients, this includes those with chronic glaucoma or certain types of eye-related issues, and they should be already receiving care at one of the trial sites. Participants will undergo tests using the new imaging method, and they will need to give their consent to take part. It's important to note that some people, such as pregnant women or those with certain eye infections, won't be eligible for this study. Overall, this trial aims to provide valuable insights into eye health, which could help improve treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Criteria common to both populations ( patients and healthy volunteers) :
• • Age ≥ 18 years and \< 75 years;
• • Having received informed information about the study and having signed a consent to participate in the study;
• • Affiliated or covered by social security
• Criteria for healthy volunteers :
• • No ocular or systemic disease deemed to affect ocular circulation by an investigator
• Specific criteria for patients:
• • Subjects usually followed at one of the recruiting centers;
• • Patients with chronic glaucoma, for whom a therapeutic modification is planned in the short term;
• • Patients with carotid stenosis;
• • Patients with choroidal pathology: pachychoroidism having led to pigment epithelium anomalies.
• Exclusion Criteria:
• * For all participants:
• • Persons covered by articles L1121-5 to L1121-8 of the CSP (all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial decision or administrative decision, minors, and persons under legal protection: guardianship or curatorship);
• • Women of childbearing age not using an effective method of contraception, or positive pregnancy test (blood or urine);
• • Participants allergic to tropicamide when using pupillary dilatation;
• • Inability of the subject to maintain a stable sitting position for research procedures;
• * Temporary contraindication to HoloDoppler:
• • Patient suffering from viral conjunctivitis or any other infectious disease;
• • Patient with skin lesions on the neck or forehead, for which contact with a chin strap is not recommended.
• • Impossibility of making acquisitions of interest (e.g. due to a pupil diameter that is too small, advanced cataracts, nystagmus, etc.).
• • Wearing glasses or contact lenses to correct a refractive disorder is not considered a criterion for non-inclusion.