The Efficacy and Adverse Reactions of Neotetracycline in the Treatment of GNB Infections

Launched by THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIVERSITY · May 19, 2025

Keywords

ClinConnect Summary

The study is a multicenter, retrospective, real-world study, through retrospective collection of cases of gram-negative bacterial infections in the First Affiliated Hospital of Nanjing Medical University, Nanjing Drum Tower Hospital, Nanjing First Hospital, Shaw Hospital Affiliated to Nanjing Medical University, Affiliated Hospital of Xuzhou Medical University, and Xuzhou Central Hospital, and 100 cases of eravacycline,300 cases of tigecycline are planned to be enrolled.

Inclusion Criteria:

Meet the clinical criteria for the diagnosis and treatment of drug-resistant gram-negative bacteria...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Meet the clinical criteria for the diagnosis and treatment of drug-resistant gram-negative bacterial infection; Acute Physiology and Chronic Health Score (APACHEII) \< 25 points; The treatment time of eravacycline or tigecycline ≥ 72 hours; Adults aged 18 and above.
• Exclusion Criteria:
• • Allergy to tetracycline antimicrobial drugs; pregnant and lactating females; Patients with advanced tumors/malignant tumors, chemoradiotherapy, severe immunodeficiency or psychiatric diseases; Patients with severe hepatic and renal insufficiency (Child-Pugh class C); Other patients who are considered by the investigator to be unsuitable for enrollment.