Impact of Probiotics on Antibiotic-associated Diarrhea in Community-acquired Pneumonia

Launched by NATIONAL HEALTH INSURANCE SERVICE ILSAN HOSPITAL · May 23, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring whether taking a special blend of probiotics can help prevent diarrhea that sometimes occurs when patients receive antibiotics for community-acquired pneumonia, which is a type of lung infection. The study aims to see if these probiotics can make a difference in reducing this side effect, which can be uncomfortable and lead to additional health issues.

To participate in the trial, you need to be an adult at least 19 years old who has been diagnosed with community-acquired pneumonia and can take medicine by mouth. However, certain people won’t be eligible, such as those who are very elderly (80 years or older), those currently experiencing diarrhea, or those recently using probiotics or laxatives. If you join the trial, you can expect to take the probiotic mixture while being closely monitored to see how it affects your health during your treatment for pneumonia. The study is not yet recruiting participants, but it could offer valuable insights into managing antibiotic side effects in pneumonia patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients aged 19 years or older admitted with a diagnosis of community-acquired pneumonia
• • Patients eligible for oral medication administration (able to take oral or enteral feeding)
• Exclusion Criteria:
• • Sepsis patients
• • Patients admitted to the intensive care unit (ICU) following endotracheal intubation
• • Elderly patients aged 80 years or older
• • Pregnant women
• • Patients who have diarrhea at the time of admission
• • Patients with a history of using probiotics within 3 months prior to admission
• • Patients with a history of using laxatives within 1 week prior to admission
• • Patients suspected of being in shock (mean arterial pressure \< 65 mmHg) at the time of admission