Lynch Syndrome in Colorectal Cancer Surgery
Launched by IZMIR ATATURK TRAINING AND RESEARCH HOSPITAL · May 17, 2025
Trial Information
Current as of July 22, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is focused on studying Lynch syndrome, a hereditary condition that increases the risk of colorectal cancer, in patients who are undergoing surgery for colorectal cancer in Türkiye. The research aims to find out how common Lynch syndrome is among these patients by looking at their cancer tissues and performing specific tests to check for genetic changes. Over the course of a year, patients aged 18 and older who have been diagnosed with colorectal cancer and are having surgery will be invited to participate. They will need to provide a sample of their tumor tissue for testing, and they must agree to participate in the study and undergo additional genetic testing if needed.
Eligible participants can expect to have their tumor analyzed to see if there are any changes related to Lynch syndrome. Depending on the results, they might undergo further genetic testing to understand their risk better. The study is not yet recruiting participants, but if you or someone you know is diagnosed with colorectal cancer and meets the eligibility criteria, this trial could provide valuable information about their health and family risk factors.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age 18 years or older
- • Histologically confirmed diagnosis of colorectal adenocarcinoma
- • Undergoing surgical resection at one of the participating general surgery departments
- • Availability of formalin-fixed, paraffin-embedded (FFPE) tumor tissue for MMR analysis
- • Consent to participate in the study and undergo genetic testing if indicated
- Exclusion Criteria:
- • Age below 18 years
- • Diagnosis other than colorectal adenocarcinoma
- • Incomplete or unavailable postoperative pathology results
- • Inadequate tissue samples for IHC analysis
- • Patients who decline participation in the study at any point
- • Patients who do not attend or refuse referral to genetic counseling after pathology results
About Izmir Ataturk Training And Research Hospital
Izmir Ataturk Training and Research Hospital is a leading medical institution in Turkey, dedicated to advancing healthcare through comprehensive clinical research and education. As a prominent sponsor of clinical trials, the hospital is committed to improving patient outcomes by exploring innovative treatments and therapies across various medical disciplines. With a focus on ethical standards and patient safety, Izmir Ataturk Hospital fosters collaboration among healthcare professionals, researchers, and regulatory bodies to ensure the successful execution of clinical studies, ultimately contributing to the enhancement of medical knowledge and practice.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported