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Search / Trial NCT06990633

Lynch Syndrome in Colorectal Cancer Surgery

Launched by IZMIR ATATURK TRAINING AND RESEARCH HOSPITAL · May 17, 2025

Trial Information

Current as of July 22, 2025

Not yet recruiting

Keywords

Lynch Syndrom, Colorectal Cancer

ClinConnect Summary

This clinical trial is focused on studying Lynch syndrome, a hereditary condition that increases the risk of colorectal cancer, in patients who are undergoing surgery for colorectal cancer in Türkiye. The research aims to find out how common Lynch syndrome is among these patients by looking at their cancer tissues and performing specific tests to check for genetic changes. Over the course of a year, patients aged 18 and older who have been diagnosed with colorectal cancer and are having surgery will be invited to participate. They will need to provide a sample of their tumor tissue for testing, and they must agree to participate in the study and undergo additional genetic testing if needed.

Eligible participants can expect to have their tumor analyzed to see if there are any changes related to Lynch syndrome. Depending on the results, they might undergo further genetic testing to understand their risk better. The study is not yet recruiting participants, but if you or someone you know is diagnosed with colorectal cancer and meets the eligibility criteria, this trial could provide valuable information about their health and family risk factors.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Age 18 years or older
  • Histologically confirmed diagnosis of colorectal adenocarcinoma
  • Undergoing surgical resection at one of the participating general surgery departments
  • Availability of formalin-fixed, paraffin-embedded (FFPE) tumor tissue for MMR analysis
  • Consent to participate in the study and undergo genetic testing if indicated
  • Exclusion Criteria:
  • Age below 18 years
  • Diagnosis other than colorectal adenocarcinoma
  • Incomplete or unavailable postoperative pathology results
  • Inadequate tissue samples for IHC analysis
  • Patients who decline participation in the study at any point
  • Patients who do not attend or refuse referral to genetic counseling after pathology results

About Izmir Ataturk Training And Research Hospital

Izmir Ataturk Training and Research Hospital is a leading medical institution in Turkey, dedicated to advancing healthcare through comprehensive clinical research and education. As a prominent sponsor of clinical trials, the hospital is committed to improving patient outcomes by exploring innovative treatments and therapies across various medical disciplines. With a focus on ethical standards and patient safety, Izmir Ataturk Hospital fosters collaboration among healthcare professionals, researchers, and regulatory bodies to ensure the successful execution of clinical studies, ultimately contributing to the enhancement of medical knowledge and practice.

Locations

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported