The Study Aims to Compare the Effectiveness of Mesoporous Bioactive Glass-containing Adhesives vs Conventional Universal Adhesives on the Clinical Performance Composite Restorations Through Promoting Dentin Remineralization After Selective Caries Removal Over a Two-year Follow-up

Launched by CAIRO UNIVERSITY · May 23, 2025

Keywords

ClinConnect Summary

This clinical trial is designed to compare two types of dental adhesives used for treating cavities in adult patients. One adhesive contains a special material called bioactive glass, which may help the tooth heal better, while the other is a traditional adhesive. The study will follow 80 adults over two years to see how well each adhesive works in terms of tooth strength, how well it fits around the filling, and whether it helps the tooth remineralize, or heal. Researchers will also check for any sensitivity or new cavities that might develop during this time.

To be eligible for this study, participants should be between 22 and 42 years old and have specific types of cavities in their back teeth. They need to have healthy teeth without serious issues and be willing to come in for follow-up appointments over the two years. It’s important for potential participants to know that they cannot have allergies to the materials used, certain dental conditions, or be pregnant. Overall, this study could help improve how dentists treat cavities and support tooth healing in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients aged 22 to 42 years.
• • Presence of Class II carious lesions in posterior permanent teeth (ICDAS 5 \& 6).
• • Radiographic evidence of caries extending to 50% of dentin with a radiopaque layer between the lesion and pulp chamber.
• • Teeth with normal pulp vitality confirmed through cold pulp sensibility test.
• • Teeth with no periapical pathosis on radiographic examination.
• • Good oral hygiene as determined by the attending clinician.
• • Willingness to sign the informed consent and comply with the 2-year follow-up protocol.
• • Cooperative patients who can attend all follow-up visits.
• Exclusion Criteria:
• • Allergy to any of the restorative materials (OptiBond Universal or Hi-Bond Universal).
• • Patients currently undergoing orthodontic treatment with fixed appliances.
• • Pregnant women or those planning pregnancy during the study period.
• • Patients with systemic diseases that could interfere with dental treatment (e.g., uncontrolled diabetes, cardiovascular diseases).
• • Use of analgesics or medications that could mask postoperative sensitivity.
• • Teeth with previous restorations or treatment in the target area.
• • Teeth exhibiting spontaneous pain or lingering pain after sensitivity testing, indicating irreversible pulpitis.
• • Negative response in cold pulp sensibility test, indicating pulp necrosis.
• • Teeth with periapical radiolucencies or signs of infection.
• • Mobile teeth due to periodontal disease or trauma.
• • Teeth with extensive structural damage, such as cusp fractures or deep cracks.
• • Patients unable to comply with the follow-up schedule.