Neuroprotection Bundles Comatose Survivors for in Cardiac Arrest Trial

Launched by XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY · May 27, 2025

Keywords

ClinConnect Summary

The LAPTOPS trial is studying a new approach to care for adults who have survived a cardiac arrest, which is when the heart stops beating. Researchers want to see if a specific set of treatments, called a neuroprotection bundle, can help improve recovery compared to standard care. This bundle focuses on managing important health factors like body temperature, oxygen levels, and blood pressure to protect the brain after a patient has regained circulation.

To participate in this trial, individuals must be between 18 and 80 years old and have had a cardiac arrest where they were successfully resuscitated without needing CPR for more than 20 minutes. They also need to be unconscious after regaining circulation. Family members will need to provide consent for participation. If eligible, participants can expect close monitoring and specific treatments aimed at improving their chances of recovery. It’s important to note that this trial is not yet recruiting participants, but it aims to gather valuable information to enhance care for future patients who experience cardiac arrest.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years and \< 80 years
• • Patients of in-hospital or out-of-hospital cardiac arrest who have returned -spontaneous circulation (ROSC) after cardiopulmonary resuscitation and do not require CPR for more than 20 minutes;
• • Patients who are unconscious after ROSC, defined as FOUR motor response score \< 4 points or GSC ≤ 8 points;
• • Family members or legal representatives signed informed consent.
• Exclusion Criteria:
• • Unwitnessed cardiac arrest, estimated time from cardiac arrest to start of CPR \> 30 minutes;
• • Time from cardiac arrest to ROSC \> 60 minutes;
• • Patients who woke up immediately after ROSC by CPR;
• • End-stage diseases;
• • Cardiac arrest considered to be caused by neurological diseases;
• • The patient was in a vegetative state before cardiac arrest;
• • The interval from the onset of cardiac arrest to enrollment is \>72 hours .