DESI - Düsseldorfer ESD Study

Launched by TORSTEN BEYNA · May 20, 2025

Keywords

ClinConnect Summary

The DESI - Düsseldorfer ESD Study is a prospective registry (observational study) in Germany that looks at how safe and effective Endoscopic Submucosal Dissection (ESD) is for removing certain gastrointestinal tumors that stay within the top layer of lining. It will collect information from about 1,000 adult patients with lesions in the esophagus, stomach, duodenum, colon, or rectum, to see how often the tumor can be removed in one piece with clean margins (an en-bloc, R0 resection), how often there are complications, and what the pathology shows after removal. The study will also track other outcomes such as complete endoscopic removal, whether the removal is considered curative under current guidelines, cases where no further treatment is needed after tumor-board review, and the rate of recurrence over time (up to about five years).

Participants are adults (18+ years) who need an ESD for a lesion in the GI tract and can give informed consent. The study uses real-world practice, so treatment decisions follow standard guidelines or discussions at a multidisciplinary tumor board. ESD is a specialized, longer procedure than some other endoscopic techniques and carries risks of complications during or after the procedure. If you participate, you can expect follow-up assessments over months to years to check margins, recurrence, and overall outcomes. The study is centered at Evangelisches Krankenhaus Düsseldorf in Germany, and it aims to improve safety, effectiveness, and patient selection for this advanced procedure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • signed consent form
• • Indication for an ESD in the oesophagus, stomach, duodenum, colon or rectum
• • Age \>18 years
• Exclusion Criteria:
• • Age \< 18 years