BREMISS : Brain Resilience Minor Stroke Study

Launched by UNIVERSITY HOSPITAL, BREST · May 21, 2025

Keywords

ClinConnect Summary

The BREMISS study, or Brain Resilience Minor Stroke Study, is a clinical trial designed to learn more about patients who have experienced a minor ischemic stroke. The goal is to gather important information that can help researchers understand how the brain responds to such strokes. If you or a loved one has had a stroke and is between the ages of 18 and 75, you might be eligible to participate in this study. To qualify, participants should have a mild stroke (with a specific scoring system rating their condition), have been followed by healthcare providers for more than four years, and be able to provide consent to join the trial.

Participants in the study will have the option to take part through a phone interview or an in-person meeting. If you choose the phone option, you will receive a saliva kit at home to collect a sample for further genetic testing, along with questionnaires to fill out. If you come in person, you’ll be able to provide a saliva sample and undergo a brain MRI, which is a type of scan that helps visualize the brain. The study aims to include around 1,000 people, and while it is not currently recruiting, it could be an opportunity to contribute to important research on stroke recovery and brain health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Cases of stroke in the Brest Stroke Registry (BSR)
• • Ability to sign informed consent
• • Patients followed-up \> 4 years during the study period
• • NIHSS score ≤ 5 on admission
• • First stroke above 18 and before 75-year old
• • Rankin before stroke \< 1
• • Possibility to draw saliva samples for genomic study
• • Possibility to perform Cerebral MRI
• Exclusion Criteria:
• • Patients with transient neurological deficits resolving within one hour and normal brain imaging will be excluded.
• • Not affiliated to social security
• • Patient under legal protection or deprived of liberty by a judicial or administrative decision
• • Patient unable to sign informed consent
• • Patient whose follow-up will be impossible