Investigation of the Correlation Between Polyamine Levels and Their Key Enzymatic Activities in Association With Inflammatory Bowel Disease Progression

Launched by XIJING HOSPITAL · May 26, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how certain substances in the body called polyamines might relate to the progression of Inflammatory Bowel Disease (IBD), which includes conditions like Ulcerative Colitis and Crohn's Disease. The researchers want to find out if measuring polyamine levels and their related enzymes can help predict how the disease will develop in patients. This could lead to better ways to monitor the disease, determine the effectiveness of treatments, and even help in choosing the right probiotics to support gut health for people with IBD.

To participate in this trial, you need to be between 18 and 65 years old and have a diagnosed case of IBD. It's important that your medical history is complete, and you must be able to provide written consent to join the study. Participants will be closely monitored, and the study aims to improve understanding of IBD and enhance treatment options. If you're considering joining, please note that individuals with specific other health issues or those who have recently taken antibiotics or probiotics may not be eligible.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age between 18 and 65 years;
• • 2. Diagnosed with inflammatory (IBD) according to the Chinese Guidelines for the Diagnosis and Treatment of Ulcerative Colitis (2023, Xi'an) and the Chinese Guidelines for the Diagnosis and Treatment of Crohn's Disease (2023, Guangzhou);
• • 3. Complete medical records available and written informed consent obtained from the participant.
• Exclusion Criteria:
• • 1. Presence of other metabolic disorders;
• • 2. History of malignant tumors, severe organ dysfunction, or other severe systemic diseases affecting major organs, or hematological disorders;
• • 3. Diagnosis of influenza, bacterial dysentery, or other infectious diseases within the past 2 weeks;
• • 4. Presence of other diseases that may interfere with polyamine metabolism;
• • 5. Use of antibiotics or probiotics within 8 weeks prior to the start of the study.