Diaphragmatic Speckle Tracking to Guide Diaphragm-Protective Ventilatory Support: A Study of Feasibility and Efficacy.

Launched by SIR RUN RUN SHAW HOSPITAL · May 29, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating a new method called diaphragmatic speckle tracking ultrasound to help improve breathing support for patients who are on mechanical ventilation due to respiratory failure. The main aim is to see if this ultrasound technique can help preserve diaphragm function and increase the chances of successfully removing patients from the ventilator, while also reducing complications that can arise from prolonged mechanical ventilation. Participants in the study will either receive ventilation support guided by this ultrasound method or the standard approach, and they will keep daily records of their symptoms and progress.

To be eligible for the trial, participants need to be at least 18 years old and have a clear diagnosis of respiratory failure, requiring breathing support for at least 24 hours. They should also be able to provide consent for participation, or have a legal guardian do so if they are unable. The trial is not yet recruiting participants, but it aims to gather important information that could lead to better care for patients needing ventilatory support in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥18 years old.
• • 2. Clear diagnosis of respiratory failure requiring respiratory support.
• • 3. Expected duration of respiratory support ≥24 hours or (high-flow/non-invasive ventilation) ≥48 hours.
• • 4. Voluntary participation in this study and signed informed consent. If the participant is unable to read or sign the informed consent form due to incapacity (e.g., unconsciousness), the legal guardian must act as a proxy in the informed consent process and sign the form. If the participant cannot read the consent form (e.g., illiterate participants), a witness must observe the informed consent process and sign the form.
• Exclusion Criteria:
• • 1. Severe chest wall deformities or diaphragmatic paralysis.
• • 2. End-stage disease with a predicted life expectancy of less than 24 hours.
• • 3. Inability to acquire STE (strains and echoes) images (e.g., severe subcutaneous emphysema, position limitations).
• • 4. Vulnerable groups other than critically ill patients/elderly/illiterate individuals, including those with mental disorders, cognitive impairments, pregnant women, etc.