Noninvasive Support Methods for Acute Respiratory Failure of Community-acquired Pneumonia

Launched by ASSIUT UNIVERSITY · May 21, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two different treatments for adults with severe pneumonia that causes breathing problems. The study will compare a method called high-velocity nasal insufflation (HVNI) to the standard treatment known as noninvasive ventilation (NIV). Both treatments aim to help patients breathe better without needing to put a tube down their throat. The main goal of the trial is to see how well each method works within 48 hours, specifically looking at whether patients need to be intubated (which means getting a breathing tube) or if they sadly pass away. Researchers will also check how comfortable patients feel, how well their lungs are working, how long they stay in the intensive care unit (ICU), and if they survive after 28 days.

To be part of the study, participants need to be at least 18 years old and have been diagnosed with pneumonia and respiratory failure. They should have symptoms that show they need extra help breathing. However, people who are very unstable, have certain medical conditions, or have specific reasons that would prevent them from using the two treatments will not be eligible. If someone joins the trial, they can expect to receive one of the two treatments and be closely monitored by healthcare professionals for their health and comfort. The trial is not yet recruiting participants, but it will aim to provide important information on how to best support patients with this serious condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • Clinical and radiographic diagnosis of CAP
• • Respiratory failure using partial pressure of oxygen (PaO₂) and fraction of inspired oxygen (FiO₂) is defined by a partial pressure of oxygen/fraction of inspired oxygen ratio (PaO₂/FiO₂) ≤ 300 mmHg or a respiratory rate (RR) ≥ 25/min
• • Informed consent obtained
• Exclusion Criteria:
• • Hemodynamic instability requiring vasopressors
• • Altered mental status Glasgow Coma Scale (GCS \< 13)
• • Contraindication to NIV or HVNI (facial trauma, recent upper airway surgery)
• • Do-Not-Intubate (DNI) order