Quadriceps Motor Unit Adaptation to Simulated Knee Injury

Launched by UNIVERSITY OF CENTRAL FLORIDA · May 30, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a simulated knee injury affects the way the quadriceps muscle behaves in healthy young adults. Researchers will create a knee injury effect in the lab and then test the participants' muscle responses during a two-hour session. The goal is to better understand how muscle inhibition works, which can help develop better treatments for people who have experienced real knee injuries.

To participate in this study, you need to be between 18 and 30 years old, physically active, and have no history of major lower limb injuries or surgeries. If you join the trial, you will undergo some neuromuscular testing, but it’s important to know that this study is not yet recruiting participants. If you have certain health conditions, anxiety about needles, or are pregnant, you may not be eligible for this trial. Overall, this research aims to provide valuable insights into how our muscles react to injury and how we can support recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age 18-30 years
• • 2. Physically active (Tegner ≥ 5)
• • 3. No prior lower-limb surgery or major injury
• Exclusion Criteria:
• • 1. Lower limb surgery or significant injury in past 2 years
• • 2. Cardiopulmonary, neurological, or psychiatric disorders
• • 3. Needle/electrical stimulation anxiety
• • 4. Medications affecting neuromuscular or psychological function
• • 5. Pregnancy
• • 6. Allergic to lidocaine
• • 7. Inability to elicit Hoffmann reflex