Exploring the Utility of [18F]3F4AP for Demyelination Imaging

Launched by YALE UNIVERSITY · May 22, 2025

Keywords

ClinConnect Summary

This clinical trial is looking into a new imaging tool called [18F]3F4AP, which may help doctors see damage to the protective covering of nerves, known as demyelination. This damage can occur in conditions like Alzheimer's Disease, Multiple Sclerosis, and spinal cord injuries. The study aims to understand how this imaging tool works in both healthy volunteers and individuals with these conditions.

To participate, you need to be between 18 and 90 years old, in good health, and able to understand and agree to be part of the study. Unfortunately, pregnant or breastfeeding women and those with certain medical conditions cannot join. If you decide to participate, you will undergo imaging tests to help researchers learn more about how [18F]3F4AP works. This information could potentially lead to better diagnosis and treatment for those with demyelinating disorders. The trial is currently seeking participants, so if you're interested, it's a good time to consider joining.

Gender

ALL

Eligibility criteria

• Inclusion:
• • 1. Male and Female subjects must be ≥18 and \<90 years of age;
• • 2. Able to understand and provide informed consent prior to study procedures
• • 3. Must be in good health
• Exclusion:
• • 1. Less than 18 years of age;
• • 2. Pregnant or breastfeeding;
• • 3. Any significant systemic illness or unstable medical condition;
• • 4. Pre-existing medical conditions or claustrophobic reactions;
• • 5. Research-related radiation exposure exceeds current PET Center guidelines (i.e. 50 mSv in the prior 12 months);
• • 6. History of a bleeding disorder or are currently taking anticoagulants.