ClinConnect ClinConnect Logo
Search / Trial NCT06999941

A Real-world Study of Deucravacitinib in the Treatment of Moderate to Severe Plaque Psoriasis With Eczematous Features

Launched by XI TAN · May 23, 2025

Trial Information

Current as of July 22, 2025

Enrolling by invitation

Keywords

ClinConnect Summary

Eczema-like psoriasis, also referred to as psoriasis-eczema overlap, is a distinct clinical and immunopathological entity that presents with features of both chronic plaque psoriasis and atopic dermatitis (AD). It is increasingly recognized in dermatological practice but remains under-characterized in the literature. Clinically, patients may exhibit erythematous, scaly plaques typical of psoriasis, alongside intense pruritus, oozing, and lichenification more typical of eczematous dermatitis. Histologically, such lesions often display psoriasiform epidermal hyperplasia with superimposed spon...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • 1.patients who present typical psoriasis and typical eczema; 2.patients present untypical psoriasis lesions, biopsy result reveals both psoriasis and eczema features; 3.BSA≥3 and IGA≥3.
  • Exclusion Criteria:① Local use of therapeutic drugs (such as glucocorticoids, calcineurin inhibitors, etc.) within 2 weeks Vitamin D derivatives, retinoid drugs); Received biological treatment within 4 weeks or 4 half lives Agents or their immunosuppressive/immunomodulatory agents (such as cyclosporine, methotrexate, JAK inhibitors);
  • Suffering from active autoimmune diseases; Active tuberculosis infection; Hepatitis B surface antigen positive; Uncontrolled systemic diseases such as heart failure, cerebrovascular disease, and liver and kidney dysfunction;
  • Known or suspected history of immunosuppression, or although the infection has disappeared, it has been assessed by the researcher as possible Frequent publication of authors;
  • History of malignant tumors in the past, or current occurrence of any malignant tumors (excluding basal tumors cured for ≥ 1 year) Cell carcinoma, local squamous cell carcinoma of the skin, or cervical cancer in situ;
  • Pregnant or lactating women, or those with pregnancy plans during the trial period.

About Xi Tan

Xi Tan is a leading clinical trial sponsor dedicated to advancing medical research and innovation. With a strong emphasis on patient safety and scientific integrity, Xi Tan specializes in the design, management, and execution of clinical trials across various therapeutic areas. The organization collaborates with healthcare professionals, regulatory bodies, and industry partners to ensure rigorous adherence to ethical standards and regulatory compliance. Committed to improving health outcomes, Xi Tan leverages cutting-edge technologies and methodologies to expedite the development of new treatments, ultimately enhancing patient care and quality of life.

Locations

Shanghai, Shanghai, China

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported