Preoperative Pregabalin vs Gabapentin in Elderly Undergoing Surgry,Controlled Trial

Launched by CAIRO UNIVERSITY · May 23, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two medications, pregabalin and gabapentin, on reducing anxiety and increasing sedation in older patients undergoing major abdominal surgery. The goal is to see which medication works better for easing anxiety before surgery and improving comfort during the procedure. The trial will include patients who are 65 years or older, scheduled for elective surgery that requires regional anesthesia, and who are in good health according to specific medical criteria.

Potential participants should be aware that the study will not include individuals with certain health issues, such as allergies to these medications, a history of chronic pain, neurological disorders, or severe cardiovascular and respiratory conditions. If you are eligible and choose to participate, you will receive either pregabalin or gabapentin about an hour before your surgery, and then the effects on your anxiety and sedation will be monitored. This research aims to provide more information on how these medications can help older adults feel more relaxed before and during surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:This study will include :
• • 1. geriatric patients, aged 65 years or older,
• • 2. Both sex,
• • 3. scheduled for elective abdominopelvic surgery with regional anesthesia
• • 4. American Society of Anesthesiologists (ASA) physical status I or II.
• Exclusion Criteria:We will exclude patients with any of the following:
• • 1. history of allergy to gabapentin or pregabalin;
• • 2. current use of gabapentin or pregabalin for other indications
• • 3. history of chronic pain or chronic daily use of analgesics; a
• • 4. history of epilepsy, other neurological disorders, cognitive impairment, or severe psychiatric disorders;
• • 5. severe cardiovascular or respiratory diseases;
• • 6. impaired renal function; and a history of drug or alcohol abuse.
• • 7. patients with anticipated prolonged duration of surgery for more than two hours