Nasal Decongestant to Reduce Perioperative Adverse Events in Children With Upper Respiratory Track Infections Having Anesthesia.

Launched by TELETHON KIDS INSTITUTE · May 22, 2025

Keywords

ClinConnect Summary

This clinical trial is designed to see if a nasal spray can help children who have a cold or upper respiratory infection breathe better during and after surgery. The researchers want to find out if using this nasal spray, which helps open up the nasal passages, can reduce breathing problems that might happen when children wake up from anesthesia or in the recovery area afterward. They will compare the nasal spray to a placebo, which looks the same but doesn’t contain any medicine, to see if it really makes a difference.

To participate in this study, children aged 1 to nearly 9 years old who have had a cold or infection in the last two weeks and are scheduled for surgery with general anesthesia may be eligible. Participants will take either the nasal spray or the placebo just before their surgery and will be closely monitored during and after the procedure for any breathing issues. Parents and children will also be asked how they felt about using the nasal spray. This study is not yet recruiting, but it aims to help improve the safety and comfort of children undergoing surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Children aged 1 to 8.99 years with a current or recent upper respiratory tract infection (\<2 weeks).
• • Undergoing interventions or surgery under general anesthesia (elective or urgent not emergency).
• Exclusion Criteria:
• • Currently taking nasal decongestants (past 24 hours) or receiving co-phenylocaine or decongestion for surgery.
• • Surgery impacting the nasal airflow, e.g. adenoidectomy, cautery of inferior turbinates.
• • Airway management with an endotracheal tube, face mask or high flow nasal oxygen.
• • Known cardiovascular, respiratory or neurological disorders giving an ASA III or above.
• • Thyroid disease.
• • Diabetes.
• • Known hypersensitivity to the interventional products.
• • Department of Child Protection and Family Services involved in their care.
• • Planned admissions to the Paediatric Intensive Care Unit (PICU).