Impact of Regional Anesthesia on Inflammatory Mechanisms During Vaso-occlusive Crisis in Sickle Cell Patients

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE LA GUADELOUPE · May 23, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how a specific type of pain relief called Regional Anesthesia (RA) can help patients with sickle cell disease during a painful episode known as a vaso-occlusive crisis (VOC). In these painful crises, blood flow is blocked, causing severe pain and other complications. The trial aims to see if RA can not only provide quick pain relief but also reduce inflammation in the body, helping patients recover faster from these episodes.

To participate in the trial, people need to be adults over 18 years old and currently experiencing a vaso-occlusive crisis. Unfortunately, pregnant or breastfeeding women, those who have had a blood transfusion in the last three months, and individuals without coverage from the French social security system cannot join. If eligible, participants can expect to receive RA for pain management and will be closely monitored throughout the study. This research is currently recruiting participants, and it aims to improve treatment options for those suffering from sickle cell disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • patients adult \>18 years
• • patients with vaso-occlusive crisis
• Exclusion Criteria:
• • Pregnant or breastfeeding women
• • Blood transfusion within the last 3 months
• • Lack of affiliation with the French social security system
• • Protected individuals