Correlation Study Between SMA Blood Flow Reactivity and Acute Gastrointestinal Injury in Critically Ill Patients

Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · May 25, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how blood flow in a specific artery, called the superior mesenteric artery (SMA), changes in critically ill patients who are receiving nutrition through a feeding tube. The researchers will use a special ultrasound technique to observe these changes after the patients eat. They want to see if there’s a link between these blood flow changes and a condition called Acute Gastrointestinal Injury (AGI), which can happen when the intestines don’t get enough blood. By understanding this relationship, the team hopes to create better nutrition plans tailored to each patient’s needs, which could help reduce complications and improve recovery.

To participate in this study, individuals must be adults between 18 and 80 years old, be expected to stay in the hospital for more than three days, and need nutrition support through feeding. However, those with severe gut diseases, gastrointestinal bleeding, or bowel obstructions, as well as pregnant or nursing women, will not be eligible. Participants will have their blood flow monitored during their hospital stay, and the insights gained could lead to safer nutrition practices for critically ill patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults aged ≥18 years and ≤80 years.
• • Admitted to the study with a expected stay of more than 72 hours.
• • Require initiation of enteral nutrition support.
• Exclusion Criteria:
• • Pre-existing severe gastrointestinal diseases.
• • Patients with gastrointestinal bleeding.
• • Patients with bowel obstruction.
• • Pregnant or lactating women.
• • Patients with contraindications to bedside Doppler ultrasound.