Comparison of the Hemodynamic Effects of Ketamine - Dexmedetomidine (Ketodex) Versus Propofol-ketamine Admixture (Ketofol) During Induction of Anesthesia in Elderly: A Randomized Controlled Study.

Launched by KASR EL AINI HOSPITAL · May 23, 2025

Keywords

ClinConnect Summary

This clinical trial is exploring the effects of two different combinations of medications used to start anesthesia in elderly patients undergoing surgery. The study compares a mix of ketamine and dexmedetomidine (called Ketodex) with another mix of propofol and ketamine (called Ketofol) to see which one has a better impact on blood circulation and heart function during the beginning of anesthesia.

To participate in this trial, you must be an elderly patient over 65 years old and scheduled for non-heart-related surgery that requires general anesthesia. Some patients may not be eligible if they have certain heart conditions, severe high blood pressure, or other specific health issues. If you join the study, you'll receive one of the medication combinations during your surgery, and the medical team will monitor your heart and blood pressure closely to see how well each option works. It's important to know that your safety is a priority, and participants will be carefully chosen based on their health status.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants will be elderly patients (\>65 years), ASA I-III, scheduled for elective non-cardiac surgery under general anesthesia.
• Exclusion Criteria:
• • Patients with severe cardiac morbidities (impaired contractility with ejection fraction \< 50%, heart block, arrhythmias, tight valvular lesions, metabolic equivalent \[MET\] less than 4, patients on angiotensin converting enzyme inhibitors and angiotensin receptor blockers medications, patients with uncontrolled hypertension, patients undergoing adrenalectomy, patients with body mass index \<18 or \> 35 Kg/m2), patient with allergy of any of the study drugs will be excluded from the study and if the patient is considered to be difficult intubation in preoperative assessment will be excluded as well.