Geometrical Influences on Atherosclerosis and Blood Flow

Launched by BANGLADESH UNIVERSITY OF ENGINEERING AND TECHNOLOGY · May 25, 2025

Keywords

ClinConnect Summary

This clinical trial, titled "Geometrical Influences on Atherosclerosis and Blood Flow," is looking at how advanced imaging and computer analysis can help identify dangerous plaque build-up in the coronary arteries, which can lead to serious heart problems like heart attacks. The study is combining a type of non-invasive imaging called Coronary Computed Tomography (CCT) with a technique that simulates blood flow (Computational Fluid Dynamics or CFD) to better understand the characteristics of these plaques and how they affect blood flow. The goal is to find high-risk plaques earlier and provide better information to doctors for decision-making.

To participate in the trial, adults aged 40 to 70 years who have symptoms of coronary artery disease, such as chest pain or shortness of breath, or have multiple risk factors like high blood pressure or diabetes, may be eligible. Participants will undergo non-invasive imaging and analysis to assess their coronary health. However, individuals with severe kidney problems, a history of allergic reactions to certain contrast dyes, or who are pregnant or breastfeeding cannot join. This trial is currently recruiting participants and aims to improve early detection of heart risks, ultimately helping to prevent serious heart events.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults aged 40-70 years.
• • Presenting with symptoms of CAD (e.g., chest pain, shortness of breath) or having multiple risk factors (e.g., hypertension, diabetes, smoking).
• • Able to provide informed consent.
• Exclusion Criteria:
• • Severe renal impairment (due to contrast media risk).
• • Previous allergic reaction to iodinated contrast media.
• • Pregnant or lactating women.