Effect of Vegan Diet on Microbiome and Metabolism

Launched by ZHUJIANG HOSPITAL · Jun 3, 2025

Keywords

ClinConnect Summary

This clinical trial is looking to understand how a vegan diet might affect health by examining changes in gut bacteria and metabolism. The study will involve healthy men and women aged 20 to 30 years. Participants will first follow a regular omnivorous diet for two weeks, then switch to a vegetarian diet for another two weeks. Researchers will analyze how these dietary changes impact the gut microbiome (the community of bacteria in our digestive system) and certain substances in the blood that relate to metabolism.

To be eligible for this study, participants must be healthy individuals within the specified age range. However, certain conditions may disqualify potential participants, such as recent use of antibiotics, hormone treatments, or medications that could interfere with metabolism. Participants should also not be smokers, heavy drinkers, or following special diets for medical reasons. Those who join the trial will help researchers learn more about the health effects of a vegan diet, and they can expect to be closely monitored during the dietary phases.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria: healthe Participants, ages 20-30 years old
• Exclusion Criteria:
• • 1. Oral antibiotic use or acute/chronic inflammation within the past 3 months;
• • 2. Hormone intake within the past 3 months;
• • 3. Use of any known interfering medications (e.g., insulin, glibenclamide, indomethacin, phentolamine, furosemide, phenytoin sodium, cortisone, etc.) or probiotics within the past month that may affect glucose or lipid metabolism;
• • 4. Smoking or alcohol consumption;
• • 5. Uncontrolled mental disorders (including a history of psychiatric hospitalization);
• • 6. Currently participating in a weight loss or weight management program;
• • 7. Following a special or medically prescribed diet (e.g., for celiac disease);
• • 8. Comorbid cardiac or renal insufficiency;
• • 9. Chronic constipation;
• • 10. Hypertension;
• • 11. Diabetes mellitus.