Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in Tracheostomized Patients Receiving Prolonged Mechanical Ventilation

Launched by NATIONAL TAIWAN UNIVERSITY HOSPITAL · May 26, 2025

Keywords

ClinConnect Summary

This clinical trial is studying why some patients with tracheostomies have difficulty transitioning off mechanical ventilation after a long period of use. Specifically, it looks at how different factors related to lung function, such as lung pressure and how well different parts of the lungs are working, may affect a patient's ability to pass a breathing test and breathe on their own. Understanding these factors can help healthcare providers improve care for patients who need prolonged mechanical ventilation.

To be eligible for this trial, participants must be at least 20 years old, have been on a ventilator for at least 14 days after a tracheostomy, and require less than 50% oxygen while on the ventilator. However, those with unstable vital signs, certain lung conditions like asthma or COPD, or specific recent surgeries may not be able to participate. If someone joins the study, they will undergo various tests to assess their lung function and may receive additional care based on the findings. This research aims to improve the chances of successfully transitioning patients off mechanical ventilation.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Post-tracheostomy patients who are transferred to the subacute respiratory care ward of National Taiwan University Hospital must use respirators for at least 14 days;
• • Be at least 20 years old;
• • The oxygen concentration required when using the respirator does not exceed 50%
• Exclusion Criteria:
• • The vital signs are unstable or require continuous use of vasopressors;
• • Pregnancy;
• • Chronic obstructive pulmonary disease or asthma;
• • Those who have contraindications to the placement of esophageal pressure balloons, such as abnormal blood coagulation, esophageal varices, and those who have undergone esophageal or gastric surgery in the past six months;
• • Those who have contraindications to the use of electrical impedance tomography, such as heart rhythm regulators.