Penthrox in Otolaryngology

Launched by SIR MORTIMER B. DAVIS - JEWISH GENERAL HOSPITAL · May 26, 2025

Keywords

ClinConnect Summary

This clinical trial, called "Penthrox in Otolaryngology," is exploring how a medication called methoxyflurane can help manage pain during certain ear, nose, and throat (ENT) procedures. The researchers want to see if using this inhaled medication along with local anesthesia makes patients feel more comfortable and satisfied during and after their procedures. They will also look at how sleepy patients feel, how much pain they report afterward, and if there are any side effects from the medication.

To participate in this study, you must be an adult planning to undergo specific procedures, such as skin lesion removal, biopsies, or ear tube insertions. However, you won’t be eligible if you are under 18, pregnant, or have certain health issues. If you join the trial, you can expect to use the inhaled medication during your procedure and will be asked to fill out a questionnaire afterward to share your experience. This study is not yet recruiting participants, so no one is enrolled at this time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * All adult patients undergoing any of the following procedures with inhaled methoxyflurane as an adjunct to topical or local anesthesia:
• • Skin lesion excision or reconstruction
• • Fine or core needle aspiration biopsy
• • Mucosal biopsy
• • Laryngeal injection or biopsy
• • Myringotomy with or without tympanostomy tube insertion
• • Inferior turbinate reduction
• • Septal button insertion
• Exclusion Criteria:
• • Patient unable to complete the post-procedure questionnaire (either due to time constraints, neurocognitive impairment, etc.)
• * Presence of any contraindications to inhaled methoxyfluorane per product monograph:
• • Patients less than 18 years of age
• • Pregnancy, intended pregnancy, or current breast-feeding
• • Inadequate patient understanding or lack of cooperation
• • Decreased level of consciousness or head injury
• • History of clinically significant renal impairment, e.g., reduced renal output
• • History of liver dysfunction following previous exposure to halogenated anesthetics
• • Current use of tetracycline antibiotics
• • Personal or genetic history of malignant hyperthermia
• • Muscular dystrophy