Ultrasound-Guided Microbubble Removal and Filter Lifespan During CRRT: A Pilot Crossover Study

Launched by FIRST AFFILIATED HOSPITAL OF WANNAN MEDICAL COLLEGE · Jun 3, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating a new method to help patients with acute kidney injury or chronic kidney disease who need a treatment called Continuous Renal Replacement Therapy (CRRT). The study will explore whether using ultrasound to remove tiny bubbles (called microbubbles) from the CRRT equipment can help the filters last longer and work better. This could mean fewer complications and a more effective treatment for critically ill patients.

Adults over 18 years old who are in the Intensive Care Unit (ICU) and are expected to receive at least two sessions of CRRT may be eligible to participate. To take part, patients or their legal representatives must agree and provide consent. During the trial, participants will experience two different methods of preparing the CRRT equipment: one using standard techniques and another using ultrasound to check for and remove microbubbles. This study aims to see if the ultrasound method is better at preventing filter clogging. Participation is voluntary, and all personal information will be kept confidential.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years, regardless of sex;
• • Admission to the intensive care unit (ICU) with a diagnosis of acute kidney injury (AKI) or chronic kidney disease (CKD) requiring continuous renal replacement therapy (CRRT);
• • Expected to receive at least two sessions of CRRT;
• • Written informed consent obtained from the patient or their legally authorized representative.
• Exclusion Criteria:
• • Presence of severe coagulopathy (such as disseminated intravascular coagulation, DIC) or platelet count \<30×10\^9/L;
• • Contraindications to anticoagulation therapy;
• • Change in APACHE II score \>5 points, or changes in coagulation parameters and platelet count exceeding 20% between the two treatment sessions;
• • Any other condition deemed unsuitable for participation by the investigators.