Use of PRP in Open Surgery for Type A Aortic Dissection

Launched by BEIJING ANZHEN HOSPITAL · Jun 3, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating whether using a treatment called autologous platelet rich plasma (PRP) during open surgery for Type A aortic dissection can help reduce the need for blood transfusions and protect important organs like the heart, liver, and kidneys. In simple terms, PRP is a substance made from a patient's own blood that contains a high concentration of platelets, which are cells that help with healing. The researchers want to see if giving PRP during surgery can lower the amount of donated blood needed and improve the health of organs during recovery.

To be eligible for this study, participants should be between 18 and 70 years old, have a body weight between 60-100 kg, and must be undergoing surgery for Type A aortic dissection. Those with certain health conditions, such as severe bleeding issues or those on specific medications, will not be included. Participants will receive an infusion of their own PRP during surgery and will have follow-up checkups to monitor their recovery, including how much blood they needed and how well their organs are functioning. This trial is not yet recruiting participants, but it aims to provide important insights into the benefits of PRP in surgical settings.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Undergoing open surgery for type A aortic dissection (TAAD);
• • 2. Body weight between 60-100 kg; hemoglobin (Hb) \> 120 g/L; platelet count (PLT) ≥ 120 × 10⁹/L;
• • 3. Able to understand the purpose of the study, voluntarily participate, and sign the informed consent form.
• Exclusion Criteria:
• • 1. Requires mechanical ventilation before surgery;
• • 2. Age under 18 or over 70 years;
• • 3. Use of anticoagulant or antiplatelet drugs within 7 days before surgery;
• • 4. Cardiogenic shock, cardiac arrest, severe hypotension (requiring two or more vasopressors), or mechanical circulatory support within 24 hours before surgery;
• • 5. Renal failure requiring dialysis;
• • 6. Severe coagulopathy or active bleeding tendency;
• • 7. Known history of heparin-induced thrombocytopenia (HIT);
• • 8. Severe psychiatric illness or other conditions affecting study reliability;
• • 9. Any condition deemed unsuitable by the investigator.