Long COVID Cutaneous Signatures: An ARPA Funded Research Project

Launched by CND LIFE SCIENCES · Jun 3, 2025

Keywords

ClinConnect Summary

This clinical trial, titled "Long COVID Cutaneous Signatures," is studying the effects of Long COVID and other related conditions on the skin and nervous system. Researchers want to understand how Long COVID affects people compared to other disorders like Acute COVID-19, Postural Orthostatic Tachycardia Syndrome (POTS), and Diabetic Neuropathy. They will include 300 participants of all genders, aged between 18 and 75 years, who meet specific criteria related to these conditions.

If you or someone you know has Long COVID, has had a positive COVID test without ongoing symptoms, has POTS, or suffers from Diabetic Neuropathy, you might be eligible to participate. During the study, participants will visit once for a thorough evaluation, which may include some tests like skin biopsies. It’s important to note that certain health issues, such as severe vascular disease or bleeding disorders, may exclude someone from joining. This trial is currently recruiting participants, and it aims to shed light on how these conditions impact people's health and well-being.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Long COVID defined by NIH PASC criteria OR 2. Acute COVID who tested positive for COVID without persistent symptoms OR 3. Postural orthostatic tachycardia syndrome (POTS) OR 4. Diabetic neuropathy
• Exclusion Criteria:
• • 1. Clinical evidence of severe peripheral vascular disease 2. History of ulceration, poor wound healing or vascular claudication 3. History of allergic reaction to local anesthesia (for biopsy collection) 4. Use of oral anticoagulants (aspirin or Plavix alone is allowed) 5. History of a bleeding disorder