Effect of Prolonged Fasting Time on Gastric Residual Volume in Patients Taking GLP1 Receptor Agonists

Launched by MAYO CLINIC · May 27, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how longer fasting times before an upper endoscopy (a procedure to look inside the stomach) might help reduce the risk of aspiration in patients taking a specific type of medication called GLP1 receptor agonists. Aspiration happens when food or liquid enters the lungs, which can be dangerous. The researchers want to see if changing how long patients fast before the procedure can make a difference in safety.

To participate, you need to be between the ages of 65 and 74 and scheduled for an elective upper endoscopy with a gastroenterologist. However, if you have certain conditions like gastroparesis (a problem with stomach emptying), achalasia (a swallowing disorder), or if you're having an urgent procedure, you won't be eligible. If you join the study, you will follow the modified fasting plan and then undergo the upper endoscopy, helping researchers gather important information to improve patient safety in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing elective upper endoscopy with gastroenterology team
• Exclusion Criteria:
• • Urgent or emergent procedure
• • Inclusion of colonoscopy or antegrade small bowel enteroscopy in planned procedure
• • Upper GI barium study performed in past 24 hours.
• • Gastroparesis
• • Achalasia
• • Pancreatitis
• • Use of outpatient pro-motility medications
• • Patient refusal
• • Inability for patient to provide own consent