Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA)

Launched by UNIVERSITY OF MIAMI · May 28, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at whether giving a one-time high dose of vitamin D to patients who have low levels before joint surgery can help reduce complications after the surgery. The study focuses on people who are scheduled to have total joint replacement surgery due to osteoarthritis, a condition that causes joint pain and stiffness. Researchers hope that by correcting vitamin D deficiency, patients may have smoother recoveries and fewer problems after their operations.

To participate in this study, you need to be between 65 and 75 years old and have low vitamin D levels (less than 30 ng/mL) measured within two weeks before your surgery. Unfortunately, some people won't be able to join, such as those with certain health conditions like cancer or liver problems, and those who are pregnant or under 18. If you decide to take part, you'll receive the vitamin D supplement before your surgery, and the researchers will monitor your recovery for about three months afterward. This trial is not yet recruiting participants, but it’s an important step in understanding how vitamin D might help improve outcomes for patients undergoing joint replacement surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Serum 25(OH)D \< 30 ng/mL within 2 weeks of surgery.
• • Able to provide informed consent.
• Exclusion Criteria:
• • Follow-up duration \< 90 days anticipated.
• • Acute hepatitis, cancer, organ transplant recipients, or dialysis patients.
• • Extra vitamin D supplementation within 90 days post-surgery.
• • Preoperative serum 25(OH)D ≥ 30 ng/mL.
• • Adults unable to consent (excluded).
• • Individuals under 18 (excluded).
• • Pregnant women (excluded).
• • Prisoners (excluded).