Effect of Intraperitoneal Insulin Administration After Laparoscopy in Insulin-Resistant Patients on Prevention of Postoperative Adhesion Recurrence: A Randomized Controlled Trial

Launched by AIN SHAMS UNIVERSITY · May 28, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating whether giving insulin directly into the abdominal area after laparoscopic surgery can help prevent the formation of scar tissue, known as adhesions, in women who have insulin resistance. Adhesions can lead to chronic pain and complications, and women with insulin resistance may be at greater risk due to their bodies’ inflammatory responses. By testing this treatment, researchers hope to find a safer and more effective way to reduce the chances of adhesions developing after surgery.

To participate in this trial, women aged 18 to 40 who have been diagnosed with insulin resistance and are scheduled for laparoscopic surgery due to issues like infertility or pelvic pain may be eligible. Participants will need to meet certain health criteria, like having a specific body mass index (BMI) and being able to provide informed consent. The trial is not yet recruiting, but if you qualify, you can expect to receive insulin treatment after your surgery and be closely monitored for any effects on adhesion formation. This study could lead to better outcomes for women facing these issues in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women aged 18-40 years
• • Diagnosed insulin resistance (e.g., HOMA-IR \>2.5 or fasting insulin \>15 uIU/mL)
• • Indicated for laparoscopy for infertility or pelvic pain
• • BMI 20-35 kg/m²
• • Able and willing to give informed consent
• Exclusion Criteria:
• • Diabetes mellitus requiring pharmacologic treatment
• • History of peritonitis or major abdominal surgery in the past 6 months
• • Known allergy or sensitivity to insulin
• • Chronic steroid or immunosuppressive use
• • Pregnancy or lactation
• • Participation in another clinical trial within the last 3 months