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Search / Trial NCT07007286

Real-world Study on Liver Cancer Risk in Chronic Hepatitis B Patients With Family History of Liver Cancer

Launched by PEKING UNIVERSITY FIRST HOSPITAL · May 28, 2025

Trial Information

Current as of July 24, 2025

Not yet recruiting

Keywords

ClinConnect Summary

This clinical trial is studying how different treatments affect the risk of liver cancer in patients with chronic hepatitis B (CHB) who have a family history of liver cancer. Researchers want to compare the long-term outcomes for patients who receive a combination of two types of medications—PEG IFNα-2b and nucleos(t)ide analogues— versus those who receive just nucleos(t)ide therapy alone. The main goal is to find out how often liver cancer occurs in these patients over a period of five years, and they will also look at other factors like liver health and survival rates.

To participate in this study, patients need to be at least 30 years old and have been diagnosed with chronic hepatitis B for more than six months. They should also have a family history of liver cancer, such as a parent or sibling who has had it. The study is open to all genders, and participants must be willing to take part and understand the study's details. Those selected will be monitored over the five years to gather important information that could help improve treatment for chronic hepatitis B in the future.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • (1) Chronic hepatitis B (CHB) patients with HBsAg positivity for over 6 months; (2) Family history of HBV-related hepatocellular carcinoma (HCC) (first- or second-degree relatives with HBV-related HCC); (3) Age ≥ 30 years, regardless of gender; (4) Based on real-world clinical practice, patients receiving nucleos(t)ide analogue (NA) therapy, such as Entecavir (ETV), Tenofovir Disoproxil Fumarate (TDF), Tenofovir Alafenamide Fumarate (TAF), or Tenofovir Amibufenamide (TMF), or those receiving combination therapy with nucleos(t)ide analogues and PEG IFNα-2b; (5) Negative pregnancy test within 24 hours before the first dose (for women of childbearing potential); (6) Voluntary participation, with the ability to understand and sign the informed consent form.
  • Exclusion Criteria:
  • (1) Patients diagnosed with hepatocellular carcinoma (HCC) or malignancies in other organ systems prior to treatment; (2) Patients with contraindications to Peg IFN α-2b (refer to the Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2022 Edition) for details); (3) Patients in the immune-tolerant phase of HBV infection; (4) Patients scheduled for or with a history of organ transplantation; (5) Patients with hypersensitivity to interferon or any contraindication listed in the drug's prescribing information; (6) Other conditions deemed unsuitable for enrollment by the investigator.

About Peking University First Hospital

Peking University First Hospital is a leading medical institution in China, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, the hospital leverages its extensive expertise in various medical fields to conduct rigorous studies aimed at improving patient outcomes and contributing to global medical knowledge. With a multidisciplinary team of skilled researchers and clinicians, Peking University First Hospital is dedicated to the ethical conduct of clinical research, ensuring the highest standards of safety and efficacy in its trials. The institution plays a vital role in translating scientific discoveries into effective treatments, thereby enhancing the quality of care for patients both locally and worldwide.

Locations

Nantong, , China

Changchun, Jilin, China

Beijing, , China

Harbin, , China

Nanjing, , China

Beijing, , China

Chengdu, Sichuan, China

Hefei, , China

Nanchang, , China

Beijing, , China

Beijing, , China

Haikou, , China

Xuzhou, , China

Shanghai, , China

Shenzhen, , China

Tianjin, , China

Fuzhou, , China

Jinan, , China

Shanghai, , China

Baotou, , China

Shenyang, , China

Yangzhou, , China

Shenzhen, , China

Wuhan, , China

Xiamen, , China

Xingtai, , China

Beijing, , China

Harbin, , China

Nanning, , China

Hefei, , China

Linyi, , China

Taiyuan, , China

Jinhua, , China

Beijing, , China

Harbin, , China

Nanjing, , China

Beijing, , China

Dalian, , China

Nanchang, , China

Chifeng, , China

Heze, , China

Laixi, , China

Linfen, , China

Qingdao, , China

Shanghai, , China

Guilin, , China

Nanjing, , China

Wenzhou, , China

Xi'an, , China

Weifang, , China

Tianjin, , China

Shenzhen, Guangdong, China

Guangzhou, , China

Shanghai, , China

Shanghai, , China

Anqing, , China

Nanchang, , China

Beijing, , China

Shenzhen, , China

Xi'an, , China

Shenyang, , China

Beijing, , China

Xining, , China

Changzhi, , China

Taiyuan, , China

Lanzhou, , China

Qingyuan, , China

Baoding, , China

Changzhi, , China

Handan, , China

Handan, , China

Mudanjiang, , China

Ningbo, , China

Yibin, , China

Zigong, , China

Ankang, , China

Chengdu, , China

Wenzhou, , China

Beijing, , China

Jiamusi, , China

Taiyuan, , China

Anqing, , China

ürümqi, , China

Suzhou, , China

Tianjin, , China

Shandong, , China

Harbin, , China

Wuhan, , China

Xiamen, , China

Xining, , China

Xuzhou, , China

Guangzhou, , China

Wuxi, , China

Lishui, , China

Linfen, , China

Liuzhou, , China

Zhanjiang, , China

Guangzhou, , China

Lianyungang, , China

Taizhou, , China

Qingdao, , China

Beijing, , China

Huainan, , China

Shangrao, , China

Beijing, , China

Jiangmen, , China

Shijiazhuang, , China

Chizhou, , China

Hefei, Anhui, China

Jinzhong, , China

Pingxiang, , China

Nanjing, , China

Beijing, , China

Fuyang, , China

Ganzhou, , China

Fuyang, , China

Jinan, , China

Suqian, , China

Nanjing, , China

Nanning, , China

Jingzhou, , China

Bozhou, , China

Shenzhen, , China

Bengbu, , China

Wuxi, , China

Huangshi, , China

Jinan, , China

Jinzhou, , China

Tianjin, , China

Yichang, , China

Harbin, , China

Suqian, , China

Dongying, , China

Hohhot, , China

Shenzhen, , China

Suzhou, , China

Fengcheng, , China

Quanzhou, , China

Beijing, , China

Liuzhou, , China

Yichun, , China

Baise, , China

Chengdu, , China

Beihai, , China

Changzhou, , China

Chengdu, , China

Dongying, , China

Handan, , China

Lanzhou, , China

Linfen, , China

Longyan, , China

Nanchang, , China

Putian, , China

Qingdao, , China

Suzhou, , China

Taiyuan, , China

Xining, , China

Yantai, , China

Zibo, , China

Heilongjiang, Heilongjiang, China

Yizheng, Jiangsu, China

Changle, Shandong, China

Junxian, Shandong, China

Pingdu, Shandong, China

Zouping, Shandong, China

Huozhou, Shanxi, China

Huozhou, Shanxi, China

Huozhou, Shanxi, China

Jiexiu, Shanxi, China

Jiexiu, Shanxi, China

Anfu, , China

Ankang, , China

Anning, , China

Anshan, , China

Anyue, , China

Baoding, , China

Baotou, , China

Baotou, , China

Beijing, , China

Beijing, , China

Beijing, , China

Beijing, , China

Beijing, , China

Bengbu, , China

Bengbu, , China

Bengbu, , China

Benxi, , China

Bihua, , China

Binzhou, , China

Binzhou, , China

Bozhou, , China

Bozhou, , China

Bozhou, , China

Cangzhou, , China

Changji, , China

Changji, , China

Changxing, , China

Changzhou, , China

Chaoyang, , China

Chaoyang, , China

Chifeng, , China

Chifeng, , China

Chuzhou, , China

Dali, , China

Dandong, , China

Daqing, , China

Datong, , China

Datong, , China

Donggang, , China

Dongguan, , China

Dongguan, , China

Dongtai, , China

Dongying, , China

Enshi, , China

Enshi, , China

Ezhou, , China

Fenyang, , China

Foshan, , China

Foshan, , China

Foshan, , China

Foshan, , China

Foshan, , China

Fuxin, , China

Fuyang, , China

Fuyang, , China

Fuyang, , China

Fuyang, , China

Fuzhou, , China

Fuzhou, , China

Fuzhou, , China

Fuzhou, , China

Ganzhou, , China

Ganzhou, , China

Ganzhou, , China

Gaomi, , China

Guangzhou, , China

Guangzhou, , China

Guangzhou, , China

Guangzhou, , China

Guangzhou, , China

Guangzhou, , China

Guangzhou, , China

Guilin, , China

Guilin, , China

Hailin, , China

Hami, , China

Hami, , China

Handan, , China

Handan, , China

Handan, , China

Handan, , China

Hangzhou, , China

Hangzhou, , China

Hangzhou, , China

Hangzhou, , China

Hanzhong, , China

Hanzhong, , China

Hanzhong, , China

Hanzhong, , China

Harbin, , China

Harbin, , China

Hebei, , China

Hefei, , China

Hefei, , China

Hefei, , China

Hegang, , China

Hegang, , China

Heihe, , China

Heihe, , China

Hengshui, , China

Hetian, , China

Hezhou, , China

Hohhot, , China

Hohhot, , China

Hohhot, , China

Hohhot, , China

Huai'an, , China

Huai'an, , China

Huai'an, , China

Huai'an, , China

Huangshan, , China

Huangshan, , China

Huangshan, , China

Huangshan, , China

Huangshi, , China

Huangshi, , China

Huangshi, , China

Hubei, , China

Ji'an, , China

Jiangmen, , China

Jianping, , China

Jiaozhou, , China

Jilin, , China

Jilin, , China

Jilin, , China

Jimo, , China

Jinan, , China

Jinan, , China

Jinan, , China

Jincheng, , China

Jincheng, , China

Jincheng, , China

Jincheng, , China

Jingzhou, , China

Jingzhou, , China

Jining, , China

Jining, , China

Jinxian, , China

Jinzhong, , China

Jinzhou, , China

Jiujiang, , China

Jiujiang, , China

Jixi, , China

Karamay, , China

Kunming, , China

Laizhou, , China

Lanzhou, , China

Lianyungang, , China

Lianyungang, , China

Lianyungang, , China

Lianyungang, , China

Linfen, , China

Linfen, , China

Linfen, , China

Linkou, , China

Linxia, , China

Linyi, , China

Longnan, , China

Longyan, , China

Longyan, , China

Longyan, , China

Longyan, , China

Lu'an, , China

Lu'an, , China

Lu'an, , China

Lu'an, , China

Lu'an, , China

Lu'an, , China

Lu'an, , China

Lu'an, , China

Lu'an, , China

Lüliang, , China

Lüliang, , China

Ma'anshan, , China

Ma'anshan, , China

Macheng, , China

Maoming, , China

Meishan, , China

Mudanjiang, , China

Nanchang, , China

Nanchong, , China

Nangong, , China

Nanjing, , China

Nanjing, , China

Nanjing, , China

Nanjing, , China

Nanning, , China

Nanning, , China

Nanping, , China

Nanping, , China

Nanping, , China

Nantong, , China

Nantong, , China

Nantong, , China

Neimeng, , China

Neimeng, , China

Neimeng, , China

Ningbo, , China

Ningcheng, , China

Ordos, , China

Panjin, , China

Pingliang, , China

Pingliang, , China

Pingliang, , China

Pingyang, , China

Putian, , China

Putian, , China

Qingdao, , China

Qingyuan, , China

Qingyuan, , China

Qingyuan, , China

Qingyuan, , China

Qingzhou, , China

Qingzhou, , China

Qinhuangdao, , China

Qinzhou, , China

Qinzhou, , China

Qiqihar, , China

Quanzhou, , China

Quanzhou, , China

Quanzhou, , China

Quanzhou, , China

Quanzhou, , China

Quanzhou, , China

Quanzhou, , China

Quanzhou, , China

Quanzhou, , China

Quanzhou, , China

Quanzhou, , China

Rizhao, , China

Rizhao, , China

Rui'an, , China

Sanming, , China

Sanming, , China

Sanming, , China

Sanming, , China

Sanming, , China

Sanming, , China

Shangcheng, , China

Shanghai, , China

Shanghai, , China

Shangli, , China

Shangrao, , China

Shangrao, , China

Shangrao, , China

Shangrao, , China

Shawan, , China

Shenyang, , China

Shenzhen, , China

Shenzhen, , China

Shenzhen, , China

Shenzhen, , China

Shenzhen, , China

Shenzhen, , China

Shenzhen, , China

Shenzhen, , China

Shenzhen, , China

Shenzhen, , China

Shenzhen, , China

Shiyan, , China

Shouguang, , China

Sichuan, , China

Songyuan, , China

Suqian, , China

Suqian, , China

Suqian, , China

Suqian, , China

Suzhou, , China

Suzhou, , China

Suzhou, , China

Suzhou, , China

Suzhou, , China

Suzhou, , China

Suzhou, , China

Suzhou, , China

Suzhou, , China

Tai'an, , China

Taihe, , China

Taiyuan, , China

Taiyuan, , China

Taizhou, , China

Taizhou, , China

Taizhou, , China

Taizhou, , China

Taizhou, , China

Tangshan, , China

Tengzhou, , China

Tianjin, , China

Tianjin, , China

Tianjin, , China

Tianjin, , China

Tongjiang, , China

Tongliao, , China

Tongling, , China

Weihai, , China

Wenzhou, , China

Wu'an, , China

Wuhai, , China

Wuhan, , China

Wuhan, , China

Wuhan, , China

Wuhan, , China

Wuhan, , China

Wuhan, , China

Wuwei, , China

Wuwei, , China

Wuxi, , China

Wuxi, , China

Wuxi, , China

Wuxi, , China

Wuxi, , China

Wuxi, , China

Wuzhou, , China

Xi'an, , China

Xiamen, , China

Xiamen, , China

Xiaogan, , China

Xiaogan, , China

Xingtai, , China

Xingtai, , China

Xingtai, , China

Xining, , China

Xinjiang, , China

Xinjiang, , China

Xintai, , China

Xiushui, , China

Xizang, , China

Xizang, , China

Xizang, , China

Xuancheng, , China

Xuancheng, , China

Xuancheng, , China

Xuzhou, , China

Xuzhou, , China

Xuzhou, , China

Xuzhou, , China

Xuzhou, , China

Xuzhou, , China

Yanan, , China

Yanan, , China

Yanbian, , China

Yanbian, , China

Yanbian, , China

Yancheng, , China

Yancheng, , China

Yancheng, , China

Yancheng, , China

Yancheng, , China

Yangquan, , China

Yangquan, , China

Yangzhou, , China

Yangzhou, , China

Yantai, , China

Yichang, , China

Yichang, , China

Yichang, , China

Yinchuan, , China

Yingkou, , China

Yingtan, , China

Yining, , China

Yining, , China

Yulin, , China

Yulin, , China

Yulin, , China

Yulin, , China

Yulin, , China

Yuncheng, , China

Yuncheng, , China

Yuncheng, , China

Yuncheng, , China

Yuncheng, , China

Yuncheng, , China

Yuncheng, , China

Zaozhuang, , China

Zhangjiakou, , China

Zhenjiang, , China

Zhenjiang, , China

Zhenjiang, , China

Zhenjiang, , China

Zhongshan, , China

Zhongshan, , China

Zibo, , China

Zibo, , China

ürümqi, , China

ürümqi, , China

Patients applied

0 patients applied

Trial Officials

Guiqiang Wang, Ph.D

Principal Investigator

Peking University First Hospital

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported