Real-world Study on Liver Cancer Risk in Chronic Hepatitis B Patients With Family History of Liver Cancer
Launched by PEKING UNIVERSITY FIRST HOSPITAL · May 28, 2025
Trial Information
Current as of July 25, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how different treatments affect the risk of liver cancer in patients with chronic hepatitis B (CHB) who have a family history of liver cancer. Researchers want to compare the long-term outcomes for patients who receive a combination of two types of medications—PEG IFNα-2b and nucleos(t)ide analogues— versus those who receive just nucleos(t)ide therapy alone. The main goal is to find out how often liver cancer occurs in these patients over a period of five years, and they will also look at other factors like liver health and survival rates.
To participate in this study, patients need to be at least 30 years old and have been diagnosed with chronic hepatitis B for more than six months. They should also have a family history of liver cancer, such as a parent or sibling who has had it. The study is open to all genders, and participants must be willing to take part and understand the study's details. Those selected will be monitored over the five years to gather important information that could help improve treatment for chronic hepatitis B in the future.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • (1) Chronic hepatitis B (CHB) patients with HBsAg positivity for over 6 months; (2) Family history of HBV-related hepatocellular carcinoma (HCC) (first- or second-degree relatives with HBV-related HCC); (3) Age ≥ 30 years, regardless of gender; (4) Based on real-world clinical practice, patients receiving nucleos(t)ide analogue (NA) therapy, such as Entecavir (ETV), Tenofovir Disoproxil Fumarate (TDF), Tenofovir Alafenamide Fumarate (TAF), or Tenofovir Amibufenamide (TMF), or those receiving combination therapy with nucleos(t)ide analogues and PEG IFNα-2b; (5) Negative pregnancy test within 24 hours before the first dose (for women of childbearing potential); (6) Voluntary participation, with the ability to understand and sign the informed consent form.
- Exclusion Criteria:
- • (1) Patients diagnosed with hepatocellular carcinoma (HCC) or malignancies in other organ systems prior to treatment; (2) Patients with contraindications to Peg IFN α-2b (refer to the Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2022 Edition) for details); (3) Patients in the immune-tolerant phase of HBV infection; (4) Patients scheduled for or with a history of organ transplantation; (5) Patients with hypersensitivity to interferon or any contraindication listed in the drug's prescribing information; (6) Other conditions deemed unsuitable for enrollment by the investigator.
About Peking University First Hospital
Peking University First Hospital is a leading medical institution in China, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, the hospital leverages its extensive expertise in various medical fields to conduct rigorous studies aimed at improving patient outcomes and contributing to global medical knowledge. With a multidisciplinary team of skilled researchers and clinicians, Peking University First Hospital is dedicated to the ethical conduct of clinical research, ensuring the highest standards of safety and efficacy in its trials. The institution plays a vital role in translating scientific discoveries into effective treatments, thereby enhancing the quality of care for patients both locally and worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Nantong, , China
Changchun, Jilin, China
Beijing, , China
Harbin, , China
Nanjing, , China
Beijing, , China
Chengdu, Sichuan, China
Hefei, , China
Nanchang, , China
Beijing, , China
Beijing, , China
Haikou, , China
Xuzhou, , China
Shanghai, , China
Shenzhen, , China
Tianjin, , China
Fuzhou, , China
Jinan, , China
Shanghai, , China
Baotou, , China
Shenyang, , China
Yangzhou, , China
Shenzhen, , China
Wuhan, , China
Xiamen, , China
Xingtai, , China
Beijing, , China
Harbin, , China
Nanning, , China
Hefei, , China
Linyi, , China
Taiyuan, , China
Jinhua, , China
Beijing, , China
Harbin, , China
Nanjing, , China
Beijing, , China
Dalian, , China
Nanchang, , China
Chifeng, , China
Heze, , China
Laixi, , China
Linfen, , China
Qingdao, , China
Shanghai, , China
Guilin, , China
Nanjing, , China
Wenzhou, , China
Xi'an, , China
Weifang, , China
Tianjin, , China
Shenzhen, Guangdong, China
Guangzhou, , China
Shanghai, , China
Shanghai, , China
Anqing, , China
Nanchang, , China
Beijing, , China
Shenzhen, , China
Xi'an, , China
Shenyang, , China
Beijing, , China
Xining, , China
Changzhi, , China
Taiyuan, , China
Lanzhou, , China
Qingyuan, , China
Baoding, , China
Changzhi, , China
Handan, , China
Handan, , China
Mudanjiang, , China
Ningbo, , China
Yibin, , China
Zigong, , China
Ankang, , China
Chengdu, , China
Wenzhou, , China
Beijing, , China
Jiamusi, , China
Taiyuan, , China
Anqing, , China
ürümqi, , China
Suzhou, , China
Tianjin, , China
Shandong, , China
Harbin, , China
Wuhan, , China
Xiamen, , China
Xining, , China
Xuzhou, , China
Guangzhou, , China
Wuxi, , China
Lishui, , China
Linfen, , China
Liuzhou, , China
Zhanjiang, , China
Guangzhou, , China
Lianyungang, , China
Taizhou, , China
Qingdao, , China
Beijing, , China
Huainan, , China
Shangrao, , China
Beijing, , China
Jiangmen, , China
Shijiazhuang, , China
Chizhou, , China
Hefei, Anhui, China
Jinzhong, , China
Pingxiang, , China
Nanjing, , China
Beijing, , China
Fuyang, , China
Ganzhou, , China
Fuyang, , China
Jinan, , China
Suqian, , China
Nanjing, , China
Nanning, , China
Jingzhou, , China
Bozhou, , China
Shenzhen, , China
Bengbu, , China
Wuxi, , China
Huangshi, , China
Jinan, , China
Jinzhou, , China
Tianjin, , China
Yichang, , China
Harbin, , China
Suqian, , China
Dongying, , China
Hohhot, , China
Shenzhen, , China
Suzhou, , China
Fengcheng, , China
Quanzhou, , China
Beijing, , China
Liuzhou, , China
Yichun, , China
Baise, , China
Chengdu, , China
Beihai, , China
Changzhou, , China
Chengdu, , China
Dongying, , China
Handan, , China
Lanzhou, , China
Linfen, , China
Longyan, , China
Nanchang, , China
Putian, , China
Qingdao, , China
Suzhou, , China
Taiyuan, , China
Xining, , China
Yantai, , China
Zibo, , China
Heilongjiang, Heilongjiang, China
Yizheng, Jiangsu, China
Changle, Shandong, China
Junxian, Shandong, China
Pingdu, Shandong, China
Zouping, Shandong, China
Huozhou, Shanxi, China
Huozhou, Shanxi, China
Huozhou, Shanxi, China
Jiexiu, Shanxi, China
Jiexiu, Shanxi, China
Anfu, , China
Ankang, , China
Anning, , China
Anshan, , China
Anyue, , China
Baoding, , China
Baotou, , China
Baotou, , China
Beijing, , China
Beijing, , China
Beijing, , China
Beijing, , China
Beijing, , China
Bengbu, , China
Bengbu, , China
Bengbu, , China
Benxi, , China
Bihua, , China
Binzhou, , China
Binzhou, , China
Bozhou, , China
Bozhou, , China
Bozhou, , China
Cangzhou, , China
Changji, , China
Changji, , China
Changxing, , China
Changzhou, , China
Chaoyang, , China
Chaoyang, , China
Chifeng, , China
Chifeng, , China
Chuzhou, , China
Dali, , China
Dandong, , China
Daqing, , China
Datong, , China
Datong, , China
Donggang, , China
Dongguan, , China
Dongguan, , China
Dongtai, , China
Dongying, , China
Enshi, , China
Enshi, , China
Ezhou, , China
Fenyang, , China
Foshan, , China
Foshan, , China
Foshan, , China
Foshan, , China
Foshan, , China
Fuxin, , China
Fuyang, , China
Fuyang, , China
Fuyang, , China
Fuyang, , China
Fuzhou, , China
Fuzhou, , China
Fuzhou, , China
Fuzhou, , China
Ganzhou, , China
Ganzhou, , China
Ganzhou, , China
Gaomi, , China
Guangzhou, , China
Guangzhou, , China
Guangzhou, , China
Guangzhou, , China
Guangzhou, , China
Guangzhou, , China
Guangzhou, , China
Guilin, , China
Guilin, , China
Hailin, , China
Hami, , China
Hami, , China
Handan, , China
Handan, , China
Handan, , China
Handan, , China
Hangzhou, , China
Hangzhou, , China
Hangzhou, , China
Hangzhou, , China
Hanzhong, , China
Hanzhong, , China
Hanzhong, , China
Hanzhong, , China
Harbin, , China
Harbin, , China
Hebei, , China
Hefei, , China
Hefei, , China
Hefei, , China
Hegang, , China
Hegang, , China
Heihe, , China
Heihe, , China
Hengshui, , China
Hetian, , China
Hezhou, , China
Hohhot, , China
Hohhot, , China
Hohhot, , China
Hohhot, , China
Huai'an, , China
Huai'an, , China
Huai'an, , China
Huai'an, , China
Huangshan, , China
Huangshan, , China
Huangshan, , China
Huangshan, , China
Huangshi, , China
Huangshi, , China
Huangshi, , China
Hubei, , China
Ji'an, , China
Jiangmen, , China
Jianping, , China
Jiaozhou, , China
Jilin, , China
Jilin, , China
Jilin, , China
Jimo, , China
Jinan, , China
Jinan, , China
Jinan, , China
Jincheng, , China
Jincheng, , China
Jincheng, , China
Jincheng, , China
Jingzhou, , China
Jingzhou, , China
Jining, , China
Jining, , China
Jinxian, , China
Jinzhong, , China
Jinzhou, , China
Jiujiang, , China
Jiujiang, , China
Jixi, , China
Karamay, , China
Kunming, , China
Laizhou, , China
Lanzhou, , China
Lianyungang, , China
Lianyungang, , China
Lianyungang, , China
Lianyungang, , China
Linfen, , China
Linfen, , China
Linfen, , China
Linkou, , China
Linxia, , China
Linyi, , China
Longnan, , China
Longyan, , China
Longyan, , China
Longyan, , China
Longyan, , China
Lu'an, , China
Lu'an, , China
Lu'an, , China
Lu'an, , China
Lu'an, , China
Lu'an, , China
Lu'an, , China
Lu'an, , China
Lu'an, , China
Lüliang, , China
Lüliang, , China
Ma'anshan, , China
Ma'anshan, , China
Macheng, , China
Maoming, , China
Meishan, , China
Mudanjiang, , China
Nanchang, , China
Nanchong, , China
Nangong, , China
Nanjing, , China
Nanjing, , China
Nanjing, , China
Nanjing, , China
Nanning, , China
Nanning, , China
Nanping, , China
Nanping, , China
Nanping, , China
Nantong, , China
Nantong, , China
Nantong, , China
Neimeng, , China
Neimeng, , China
Neimeng, , China
Ningbo, , China
Ningcheng, , China
Ordos, , China
Panjin, , China
Pingliang, , China
Pingliang, , China
Pingliang, , China
Pingyang, , China
Putian, , China
Putian, , China
Qingdao, , China
Qingyuan, , China
Qingyuan, , China
Qingyuan, , China
Qingyuan, , China
Qingzhou, , China
Qingzhou, , China
Qinhuangdao, , China
Qinzhou, , China
Qinzhou, , China
Qiqihar, , China
Quanzhou, , China
Quanzhou, , China
Quanzhou, , China
Quanzhou, , China
Quanzhou, , China
Quanzhou, , China
Quanzhou, , China
Quanzhou, , China
Quanzhou, , China
Quanzhou, , China
Quanzhou, , China
Rizhao, , China
Rizhao, , China
Rui'an, , China
Sanming, , China
Sanming, , China
Sanming, , China
Sanming, , China
Sanming, , China
Sanming, , China
Shangcheng, , China
Shanghai, , China
Shanghai, , China
Shangli, , China
Shangrao, , China
Shangrao, , China
Shangrao, , China
Shangrao, , China
Shawan, , China
Shenyang, , China
Shenzhen, , China
Shenzhen, , China
Shenzhen, , China
Shenzhen, , China
Shenzhen, , China
Shenzhen, , China
Shenzhen, , China
Shenzhen, , China
Shenzhen, , China
Shenzhen, , China
Shenzhen, , China
Shiyan, , China
Shouguang, , China
Sichuan, , China
Songyuan, , China
Suqian, , China
Suqian, , China
Suqian, , China
Suqian, , China
Suzhou, , China
Suzhou, , China
Suzhou, , China
Suzhou, , China
Suzhou, , China
Suzhou, , China
Suzhou, , China
Suzhou, , China
Suzhou, , China
Tai'an, , China
Taihe, , China
Taiyuan, , China
Taiyuan, , China
Taizhou, , China
Taizhou, , China
Taizhou, , China
Taizhou, , China
Taizhou, , China
Tangshan, , China
Tengzhou, , China
Tianjin, , China
Tianjin, , China
Tianjin, , China
Tianjin, , China
Tongjiang, , China
Tongliao, , China
Tongling, , China
Weihai, , China
Wenzhou, , China
Wu'an, , China
Wuhai, , China
Wuhan, , China
Wuhan, , China
Wuhan, , China
Wuhan, , China
Wuhan, , China
Wuhan, , China
Wuwei, , China
Wuwei, , China
Wuxi, , China
Wuxi, , China
Wuxi, , China
Wuxi, , China
Wuxi, , China
Wuxi, , China
Wuzhou, , China
Xi'an, , China
Xiamen, , China
Xiamen, , China
Xiaogan, , China
Xiaogan, , China
Xingtai, , China
Xingtai, , China
Xingtai, , China
Xining, , China
Xinjiang, , China
Xinjiang, , China
Xintai, , China
Xiushui, , China
Xizang, , China
Xizang, , China
Xizang, , China
Xuancheng, , China
Xuancheng, , China
Xuancheng, , China
Xuzhou, , China
Xuzhou, , China
Xuzhou, , China
Xuzhou, , China
Xuzhou, , China
Xuzhou, , China
Yanan, , China
Yanan, , China
Yanbian, , China
Yanbian, , China
Yanbian, , China
Yancheng, , China
Yancheng, , China
Yancheng, , China
Yancheng, , China
Yancheng, , China
Yangquan, , China
Yangquan, , China
Yangzhou, , China
Yangzhou, , China
Yantai, , China
Yichang, , China
Yichang, , China
Yichang, , China
Yinchuan, , China
Yingkou, , China
Yingtan, , China
Yining, , China
Yining, , China
Yulin, , China
Yulin, , China
Yulin, , China
Yulin, , China
Yulin, , China
Yuncheng, , China
Yuncheng, , China
Yuncheng, , China
Yuncheng, , China
Yuncheng, , China
Yuncheng, , China
Yuncheng, , China
Zaozhuang, , China
Zhangjiakou, , China
Zhenjiang, , China
Zhenjiang, , China
Zhenjiang, , China
Zhenjiang, , China
Zhongshan, , China
Zhongshan, , China
Zibo, , China
Zibo, , China
ürümqi, , China
ürümqi, , China
Patients applied
Trial Officials
Guiqiang Wang, Ph.D
Principal Investigator
Peking University First Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported