Bile Omics for Diagnosing Indeterminate Biliary Strictures

Launched by SHANGHAI GENERAL HOSPITAL, SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE · Jun 5, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to diagnose certain types of cancer and bile duct problems. Specifically, it focuses on patients with biliary strictures—narrowing of the bile ducts that can be caused by cancer, but are sometimes hard to diagnose. Researchers want to see if analyzing bile (the fluid made by the liver) can help find specific markers that indicate the presence of cancer. By combining this analysis with existing testing methods, they hope to improve the accuracy of diagnoses for conditions like cholangiocarcinoma (bile duct cancer) and pancreatic cancer.

To participate in this trial, you need to be between 18 and 90 years old and have a biliary stricture that has not been clearly diagnosed. You also need to have undergone a procedure called ERCP, where doctors take samples from the bile ducts. However, if you have certain health issues, like bleeding disorders or are pregnant, you may not be eligible. If you join, you can expect to provide a bile sample, which will be analyzed to help researchers better understand how to diagnose these serious conditions. This trial is currently recruiting participants, so if you or someone you know might qualify, it could be a valuable opportunity to contribute to important medical research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Indeterminate biliary strictures
• • Aged 18-90 years
• • Underwent ERCP with biliary biopsy and/or brush cytology
• Exclusion Criteria:
• • Coagulation disorders
• • Pregnancy
• • Malignancies of other organs unrelated to biliary strictures
• • Declined participation