Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children

Launched by KBC SPLIT · May 29, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the use of a special substance called Prostaglandin E urinary metabolites (PGE-M) to help doctors identify acute appendicitis in children. Acute appendicitis is a common condition where the appendix becomes inflamed, and timely diagnosis is crucial to prevent complications or unnecessary surgeries. The researchers want to see if measuring the levels of PGE-M in the urine can help doctors make a more accurate diagnosis when children come in with abdominal pain.

The study is looking for children aged 5 to 17 years who are experiencing acute abdominal pain and show signs of appendicitis. It will include about 100 participants over a year, and in addition to standard tests, their urine will be tested for PGE-M levels. The trial poses minimal risks, and children with certain conditions, like chronic diseases or those who have had previous abdominal surgeries, won't be eligible to participate. This research could potentially improve the way appendicitis is diagnosed in children, leading to better outcomes for young patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • children of age 5 -17 years with acute abdominal pain
• • children with clinical signs of acute appendicitis
• Exclusion Criteria:
• • previous diagnosis of chronic and/or malignant disease
• • children who had previous abdominal surgery
• • pregnancy