Effect of Amitriptyline and Trifluoperazine on Patients With Functional Dyspepsia

Launched by MD. MOKTADIRUL HOQUE SHUVO · Jun 4, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how effective two medications, amitriptyline and trifluoperazine, are in treating symptoms of functional dyspepsia, which is a condition that causes discomfort or pain in the upper abdomen. The trial aims to see if these medications can help improve symptoms compared to standard treatment. Researchers will also keep track of any side effects participants may experience while taking these medications to ensure they are safe.

To participate in this trial, you need to be at least 18 years old and have been diagnosed with functional dyspepsia. You should not have certain health issues, such as serious liver problems or a history of specific cancers, and you should not be pregnant or breastfeeding. If you join, you will take either amitriptyline or trifluoperazine along with standard treatment for 8 weeks, and then you will continue with only the standard treatment for an additional 4 weeks. Throughout the trial, you will visit the hospital every four weeks to discuss your symptoms and any side effects you may have experienced.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18 years or more
• • Patients with FD diagnosed according to ROME IV criteria
• • Patients who are willing to sign informed written consent
• Exclusion Criteria:
• • Structural lesion in endoscopy and positive CLO test
• • Patients scoring 1 or 2 on the 5-point Likert scale for all four dyspepsia symptoms
• • History of malignancy, liver and biliary tract disease, diabetes mellitus, chronic kidney disease
• • Major medical and psychiatric disorders
• • Previous history gastrointestinal surgery
• • Any patient with ongoing treatment with antidepressants or antipsychotics
• • Any history of hypersensitivity, adverse effect, or ineffectiveness with amitriptyline or trifluoperazine
• • Patients for whom Amitriptyline and Trifluoperazine are contraindicated
• • Elderly patients\> 60 years
• • Pregnancy and breastfeeding