Safety and Efficacy of Exercise in Type-B Aortic Dissection

Launched by GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL · May 29, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how safe and effective exercise-based rehabilitation is for patients with Type B Aortic Dissection who have had a specific type of surgery called endovascular repair. The researchers want to find out if participating in a guided exercise program for three months, in addition to usual care, can help these patients without causing any harm.

To be eligible for this study, participants need to have had a diagnosis of Type B Aortic Dissection or related conditions and must have undergone the surgery at least one month ago without any complications. They should also be able to perform basic daily activities independently. If you join this trial, you will be randomly assigned to either receive the exercise program or continue with standard care. The goal is to see how exercise might improve your recovery and overall health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with a previous diagnosis of type B aortic dissection or intramural hematoma or penetrating ulcer, who underwent endovascular aortic repair (EVAR) or EVAR + supra-aortic shunt surgery for more than 1 month, and no related complications (such as endoleak, stent thrombosis, dissection progression, etc.) were found in the postoperative aortic CTA;
• • Able to independently carry out basic daily life activities, participants must be able to complete the baseline assessment and start the designated treatment;
• • Patients voluntarily participate in this study, sign the written informed consent, and are willing to cooperate with the follow-up;
• Exclusion Criteria:
• • Acute myocardial infarction occurred 1 month ago;
• • Combined with severe aortic stenosis or regurgitation;
• • Combined with ascending aortic aneurysm or dissection;
• • Acute heart failure occurred 2 weeks ago;
• • Combined with severe hypertrophic obstructive cardiomyopathy;
• • Chronic renal failure stage 5, which is defined as glomerular filtration rate \<15ml/(min·1.73m2) or dialysis;
• • During the screening examination, the patient's alanine aminotransferase or aspartate aminotransferase is greater than or equal to 5 times the upper limit of the normal value specified by our center;
• • Patients with any medical history that may affect compliance with the program;
• • Patients with severe language, mental or physical disabilities who are unable to participate in the program;
• • Pregnant or lactating women, or those with fertility who are unwilling/unable to take effective contraceptive measures;
• • Patients participating in other interventional clinical trials;
• • Patients with long-term high-intensity exercise habits;
• • Patients who are judged by the researchers to be unsuitable for participation in this study;