Nalbuphine Dosing and Its Impact on Anxiety and Depression in Ectopic Pregnancy Surgery

Launched by CHENGDU JINJIANG MATERNITY AND CHILD HEALTH HOSPITAL · Jun 6, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different doses of a medication called nalbuphine can affect anxiety and depression in women undergoing surgery for ectopic pregnancy, which is when a fertilized egg grows outside the uterus. Ectopic pregnancies can cause emotional distress, so the researchers want to see if nalbuphine, combined with another medication for pain relief, can help improve both physical and emotional recovery after surgery. The study will involve 165 women who are at least 18 years old and have been diagnosed with ectopic pregnancy. They will be randomly divided into three groups, each receiving a different dose of nalbuphine.

If you are eligible and participate, you can expect to receive either a lower or higher dose of nalbuphine after your surgery. The researchers will monitor your anxiety and depression levels three days after the surgery, as well as how much pain you experience and whether you need any additional pain relief. To join the study, you should be generally healthy, planned for a specific type of surgery, and able to understand the study process. Some people may not be able to participate, such as those with a history of mental illness or certain allergies. This trial has ethical approval and is aimed at helping improve recovery for women facing this challenging situation.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Confirmed diagnosis of ectopic pregnancy, aged ≥18 years, and with normal psychological status.
• • 2. Patients planned to undergo single-port laparoscopic surgery under general anesthesia, followed by postoperative patient-controlled intravenous analgesia (PCIA).
• • 3. Patients classified as ASA I or II.
• • 4. Able to understand the study process and methods, voluntarily participate, and sign the informed consent form.
• Exclusion Criteria:
• • 1. Patients using other analgesic methods or multiple analgesic approaches.
• • 2. Patients with a history of allergies or allergies to anesthetic drugs.
• • 3. Patients with a history of depression or mental illness.
• • 4. Patients with other severe organ dysfunction.
• • 5. Patients unable to operate the intravenous analgesia pump independently.