Timing of Aminophylline and Recovery in Pediatric Ambulatory Surgery

Launched by HANY MOHAMMED EL-HADI SHOUKAT MOHAMMED · May 30, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how the timing of a medication called aminophylline affects the recovery of children after surgery. Aminophylline is usually used to help with breathing problems, but it may also help children wake up more quickly and feel better after being under anesthesia during surgery. In this study, researchers will compare the effects of giving aminophylline early versus late during surgery in kids aged 4 to 12 who are having minor, same-day surgeries that last less than three hours.

To participate in this trial, children need to be between 4 and 12 years old and have no serious health issues that could complicate the surgery. Parents will need to agree to their child's participation. Participants will be randomly assigned to one of three groups: one group will receive aminophylline early during surgery, another group will receive it later, and the third group will receive a placebo (a harmless saline solution) after the anesthesia is stopped. This trial aims to find out the best way to use aminophylline to help children recover safely and quickly after their procedures.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age from 4 to 12 years.
• • Both sexes.
• • American society of Anesthesiologist (ASA) physical status I-II.
• • Scheduled for pediatric ambulatory elective surgical procedures lasting ≤ three hours duration.
• Exclusion Criteria:
• • Parents refusal to participate.
• • Conditions and diseases interfering with ambulatory day case surgery e.g., significant respiratory diseases, morbid obesity, obstructive sleep apnea, sickle cell anemia, prematurity, D.M, and family history of malignant hyperthermia.
• • Laparoscopic, endoscopic or abdominal surgeries.
• • History of cardiac arrhythmia or palpitation.
• • Patients with congenital heart, significant cardiovascular, respiratory diseases, renal impairment, hepatic dysfunction, hypo/hyperthyroidism or active peptic ulcer disease.
• • Patients with neurological, psychiatric diseases, cognitive dysfunction, epilepsy or history of convulsions.
• • Current treatment with xanthines or patient received aminophylline in the previous 24 hr. Hypersensitivity to aminophylline or other methylxanthines.
• • Patients who need alteration in the sevoflurane concentration due to either hypo/hypertension were excluded from the study and replaced.