Exploring the Mechanisms of Postoperative Delirium in Cirrhotic Patients Through Multi-Omics Integrative Analysis

Launched by SICHUAN PROVINCIAL PEOPLE'S HOSPITAL · Jun 2, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating memory problems that can happen after surgery in people with liver disease, specifically looking at stomach surgery. Researchers want to find out if individuals with liver disease experience memory issues more often than those without liver disease and whether changes in stomach bacteria and body chemicals might be linked to these memory problems. Understanding these connections could help doctors find new ways to prevent memory issues in patients with liver disease after surgery.

Adults aged 18 to 80 who are scheduled for upper abdominal surgery can participate, whether or not they have liver disease. Participants will take memory tests before and after their surgery and provide stool and blood samples during the study. This research is important because memory problems can complicate recovery after surgery, and finding the causes could lead to better care for patients with liver disease in the future. The study is not yet recruiting participants, so there will be more information available soon.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age: 18-80 years
• • 2. Patients with or without liver cirrhosis scheduled for upper abdominal surgery due to various clinical indications
• • 3. Ability to comply with the study protocol and provide informed consent
• Exclusion Criteria:
• • 1. Comorbid severe cardiac, pulmonary, or renal diseases
• 2. Patients with mental status incompatible with study participation, including:
• • Psychiatric disorders
• • Inability to communicate clearly
• • 3. Any condition preventing effective communication or cooperation