Intraoperative Continuous Lidocaine Infusion in Laparoscopic Liver Surgery

Launched by MEDICAL UNIVERSITY OF WARSAW · Jun 4, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating how a continuous infusion of lidocaine, a local anesthetic, during laparoscopic liver surgery affects pain after the operation. Researchers want to find out if this treatment can reduce the amount of pain medication needed after surgery, help patients recover their gut function faster (like passing gas or having a bowel movement), and check if it has any impact on insulin resistance, which is how the body responds to sugar. Participants will receive either the lidocaine infusion or a placebo, which is a harmless substance that looks the same but contains no medicine.

To be eligible for this trial, participants need to be adults over 18 years old who are scheduled for laparoscopic liver surgery and classified as having a low to moderate health risk. However, those with certain medical conditions, such as allergies to lidocaine, serious heart or liver issues, or chronic pain problems, won't be able to join. During the trial, participants will be monitored for their pain levels and how quickly they recover, as well as have their blood tested to check their glucose and insulin levels. This study aims to improve postoperative care for patients undergoing liver surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age \>18 years old
• • patients scheduled for laparoscopic liver surgery
• • patients classified as American Society of Anesthesiology (ASA) physical status I- III
• Exclusion Criteria:
• • medical history of seizure disorders
• • allergy to Lidocaine
• • cardiac rhythm disorders (e.g. sick sinus syndrome, Adams-Stockes syndrome, II- and III-degree AV blocks, double- bundle branch block, HR \< 50/min)
• • systolic heart failure (ejection fraction \<50%)
• • hepatic dysfunction (aspartate aminotransferase or alanine transaminase or total bilirubin \>2.5 times the upper limit of normal)
• • renal impairment (GFR \< 50ml/min/1.73 m2)
• • weight less than 45 kg, BMI \> 30
• • metastases occurring in other distant organs
• • recent use of any analgesic medication within 48h before surgery
• • history of alcohol or substance abuse
• • chronic pain syndrome
• • chronic opioid use
• • inability to comprehend NRS or complete questionnaires due to language barrier or cognitive impairment