Comparative Study Between the Effect of Dexmedetomidine ,Midazolam or Bupivacaine Packing During FESS on Surgical Field Visualization

Launched by MINIA UNIVERSITY · Jun 2, 2025

Keywords

ClinConnect Summary

This study is testing whether putting a small amount of a medication into the nose (through a 5 ml nasal packing solution) can improve visibility in the surgical field during functional endoscopic sinus surgery (FESS) under general anesthesia. The research compares four groups in a randomized, double-blind setup: saline (placebo) as the control, and nasal packing with one of three drugs—dexmedetomidine, midazolam, or bupivacaine. The main goal is to see which method best keeps the surgical area clear, measured during up to about 2 hours of surgery. Researchers will also look at how much nitroglycerine is needed to manage blood pressure, surgeon satisfaction, and intraoperative vital signs.

To be eligible, adults aged 16–60 with a body mass index (BMI) up to 30 and good overall health (ASA I–II) can participate, regardless of sex. Exclusion criteria include allergies to the study drugs, pregnancy, significant liver, kidney, or heart disease, previous nasal surgeries, or certain psychiatric conditions. The study is being conducted at Minia University in Egypt and is currently enrolling participants, with results expected after completion planned for late 2025.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • both sexes
• • aged between 16 and 60 years old
• • with BMI up to 30
• • with ASA physical status I \& II.
• Exclusion Criteria:
• • Patients with a history of allergy to the study drugs.
• • Pregnant and lactating females.
• • Patients with severe liver, renal, or cardiac diseases
• • Patients with repeated nasal surgeries.
• • Patients with psychiatric conditions.