Pathogenic Mechanisms Involved in the Initiation and Progression of Systemic Sclerosis

Launched by UNIVERSITÉ CATHOLIQUE DE LOUVAIN · Jun 2, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a condition called scleroderma, which can cause skin changes and other symptoms. Researchers want to understand the genetic factors and biological processes that lead to this disease by looking at specific genes and pathways in patients with scleroderma who do not have a family history of the condition. They will analyze skin samples from patients to see how these genes behave in people with and without skin thickening, which is a common symptom.

To participate in the trial, individuals must be between the ages of 18 and 80 and have a diagnosis of limited or diffuse scleroderma. Unfortunately, people with other autoimmune diseases, those who are pregnant, or those who cannot provide consent will not be eligible. Participants will undergo various tests, including blood draws and skin biopsies, to help researchers learn more about the disease. It's important to note that this trial has not yet started recruiting participants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Patients diagnosed with one of the following:
• • Limited SSc
• • Limited cutaneous SSc
• • Diffuse cutaneous SSc
• • Patients followed regularly in consultations at CUSL.
• • Patients between ages 18-80.
• Exclusion Criteria:
• • Other (co-occurring) autoimmune/autoinflammatory disease
• • Pregnancy
• • Participants with temporary or definitive disabilities to give consent
• • Participants unable to sign or read the inform consent form