Role of Manuka Honey in Lowering Pain and Boosting Healing After Gum Graft Surgery.

Launched by NANCY MOURADIAN · Jun 3, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of medical grade Manuka honey on pain and healing after gum graft surgery, which is a procedure to fix gum recession. The researchers want to find out if applying Manuka honey can help reduce pain and the need for pain medications, as well as improve healing at the surgery site. Participants will undergo two surgeries: one with Manuka honey applied in a retainer and one without. They will track their pain levels and medication use through daily surveys and have follow-up visits for six weeks after each surgery.

To join the study, participants need to be at least 18 years old, in good health, and have specific gum health conditions that require two gum surgeries. Important factors for eligibility include having a healthy mouth and good oral hygiene. Participants should expect to visit the clinic multiple times for surgeries and follow-ups, as well as complete surveys about their experiences. This trial is not yet recruiting, and all genders are welcome to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Participants must :
• • Be 18 years of age or older.
• • Be in good systemic health or have well-controlled systemic health.
• • Have a healthy or stable periodontium after conventional periodontal treatment.
• • Have good clinical gingival health or gingivitis on an intact or reduced periodontium, with or without a history of periodontitis
• • Maintain good oral hygiene.
• • Have a simplified plaque index and gingival bleeding index below 20%
• • Require two mucogingival surgeries involving bilateral epithelial-conjunctival graft harvesting (free gingival graft or de-epithelialised connective tissue graft).
• • The surgeries must treat single or multiple gingival recessions, or mucogingival defects around teeth or implants.
• Exclusion Criteria:
• • Smokers or users of other tobacco products
• • Pregnant participants
• • Participants who are uncooperative or have a psychological condition that makes free and informed consent or compliance with instructions impossible
• • Participants with a condition that impairs healing (e.g. poorly controlled diabetes, coagulation disorder, etc.) or the objective assessment of pain at the sampling site (e.g. autoimmune diseases, orofacial pain, etc.)
• • Participants regularly taking the following medications : non-steroidal anti-inflammatory drugs, bisphosphonates, sedatives, psychotropic drugs and corticosteroids.
• • During the study, those who develop a condition that interferes with healing, become smokers, start medication that acts on the central nervous system, do not adhere strictly to instructions or do not respect follow-ups.
• • Participants who have already received a palatal surgery in the past or whose palatal tissue thickness is less than 3 mm will not be excluded, to allow comparative analyses in sub-groups.