Inspiratory Work of Breathing Before and After Extubation

Launched by UNIVERSITY HEALTH NETWORK, TORONTO · Jun 3, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how well patients breathe before and after they are taken off a ventilator, which is a machine that helps them breathe when they can't do it on their own. The focus is on patients who have received a lung transplant or are critically ill and need help breathing. The research team at Toronto General Hospital wants to compare different methods of testing how ready a patient is to breathe on their own, using new technology to measure lung function and the effort it takes for patients to breathe.

To be eligible for this trial, participants must be adult patients who have been intubated and on a ventilator. However, there are some exclusions, such as patients who have recently had certain types of surgery or have specific medical conditions that would prevent them from safely participating. If someone joins the trial, they can expect to undergo tests that involve breathing support while their lung function is closely monitored. The goal is to gather important information that could help improve the care of patients who need respiratory support in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients intubated and ventilated
• Exclusion Criteria:
• • Contraindication for esophageal catheter insertion: upper gastrointestinal surgery within prior 6 weeks, actively bleeding esophageal varices
• • Bronchopleural fistula
• • Contraindication for electrical impedance tomography: chest burns, skin lesions in the thorax, chest wall bandaging limiting electrode placement, unstable spinal lesions or fractures
• • Pregnancy