Expression of Genes Relating Hypertension and Efficacy of 4-7-8 Breathing Control on Reducing Blood Pressure

Launched by BURAPHA UNIVERSITY · Jun 10, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two important areas related to high blood pressure, also known as hypertension. The first part of the study explores how certain genes might influence the risk of developing hypertension in people from Thailand. The second part tests a breathing technique called "4-7-8 breathing" to see if it can help lower blood pressure in those who already have hypertension.

To participate in the trial, you need to be between 18 and 59 years old, of Thai ethnicity, and live in the eastern region of Thailand. If you have hypertension, your blood pressure must be 140/90 mmHg or higher, or you must be on medication for it. If you don’t have high blood pressure, your levels should be below 130/85 mmHg, and you shouldn't have a history of hypertension. Participants can expect to contribute to important research that may help others with high blood pressure, but they should also know that certain health conditions, like heart disease or obesity, may prevent them from joining the study.

Gender

ALL

Eligibility criteria

• Study 1:
• • 1. Group of individuals with hypertension
• Inclusion Criteria:
• • Male or female
• • Aged between 18-59 years
• • Of Thai ethnicity
• • Diagnosed with hypertension, defined as having an SBP of 140 mmHg or higher, or a DBP of 90 mmHg or higher, or having previously been diagnosed with hypertension and currently taking antihypertensive medication
• • Originally from various regions of Thailand and currently residing in the eastern region
• Exclusion Criteria:
• • Has heart disease, such as valvular stenosis or regurgitation, coronary artery disease, or heart failure
• • Has obesity, defined as having a body mass index (BMI) of 30 kg/m² or higher
• • Has a fever or is currently experiencing an infectious disease, such as COVID-19, the flu, or other infections
• • 2. Group of individuals with normal blood pressure
• Inclusion Criteria:
• • Male or female
• • Aged between 18-59 years
• • Of Thai ethnicity
• • Does not have hypertension, defined as having an SBP below 130 mmHg and a DBP below 85 mmHg, with no prior diagnosis of hypertension and no history of taking antihypertensive medication
• • Originally from various regions of Thailand and currently residing in the eastern region
• Exclusion Criteria:
• • Has heart disease, such as valvular stenosis or regurgitation, coronary artery disease, or heart failure
• • Has obesity, defined as having a body mass index (BMI) of 30 kg/m² or higher
• • Has a fever or is currently experiencing an infectious disease, such as COVID-19, the flu, or other infections
• Study 2:
• Inclusion Criteria:
• • Male or female, aged 35-59 years
• • Diagnosed with hypertension, with blood pressure levels above the normal range, defined as SBP of 130 mmHg or higher, or DBP of 85 mmHg or higher, and currently taking medication
• • Originally from various regions of Thailand and currently residing in the eastern region
• • Able to communicate effectively
• Exclusion Criteria:
• • Has respiratory diseases, cardiovascular diseases, cerebrovascular disease, kidney disease, cancer, or immune-related conditions such as allergies, autoimmune diseases (e.g., SLE), immunodeficiency, or rheumatoid arthritis
• • Is obese, defined as having a body mass index (BMI) of 30 kg/m² or higher
• • Has a fever or is currently infected, such as with COVID-19, the flu, or other infectious diseases
• • Is currently pregnant, breastfeeding, or has a history of pregnancy within the 6 months prior to participating in the study