Echocardiographic Parameters for Hemodynamic Support During CVVHDF

Launched by KANUNI SULTAN SULEYMAN TRAINING AND RESEARCH HOSPITAL · Jun 5, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how certain heart ultrasound measurements can help predict whether patients in intensive care will need extra support during a specific type of dialysis called sustained low-efficiency daily dialysis (SVVHDF). The researchers will look at heart function indicators, such as how well blood flows from the heart and how the heart's chambers are moving. By taking these measurements before starting dialysis, they hope to find out which indicators can best predict if a patient will experience low blood pressure or need medications to support their heart during the first hour of treatment.

To participate in this trial, patients must be at least 18 years old, be in an intensive care unit, and require this type of dialysis. They also need to be able to get good images from a heart ultrasound. However, patients with certain heart conditions, severe lung disease, or those who may not survive for long are excluded. If eligible, patients will have a heart ultrasound done before beginning dialysis, and the goal is to personalize their treatment and improve safety during a critical time in their care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years
• • Admission to the intensive care unit (ICU)
• • Clinical indication for initiation of continuous veno-venous hemodiafiltration (CVVHDF)
• • Ability to obtain adequate transthoracic echocardiographic (TTE) images prior to CVVHDF
• • Written informed consent obtained from the patient's legal representative
• Exclusion Criteria:
• • Acute coronary syndrome, severe valvular disease, or pericardial effusion affecting cardiac function
• • Cardiac arrhythmias such as atrial fibrillation or ventricular tachycardia that interfere with accurate Doppler measurements
• • Presence of cardiac devices such as pacemakers, LVADs, or implantable cardioverter defibrillators (ICDs)
• • Poor echocardiographic window due to severe lung disease or chest wall abnormalities
• • Estimated life expectancy \<24 hours or do-not-resuscitate (DNR) orders in place
• • Inability to obtain informed consent due to lack of legal representative
• • Transfer to another facility before CVVHDF initiation or change in renal replacement strategy (e.g., switch to peritoneal dialysis)
• • Incomplete echocardiographic measurement due to technical limitations