Safety of Etomidate-propofol Mixture vs. Propofol for Total Intravenous Anesthesia in Elderly Patients Undergoing Abdominal Surgery

Launched by TONGJI HOSPITAL · Jun 12, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at the safety of a combination of two medications, etomidate and propofol, compared to using propofol alone for total intravenous anesthesia in older patients who are having abdominal surgery. The goal is to see which option is safer for this age group, which is particularly important because older patients may have different health needs and risks.

To be eligible for the trial, participants should be between 65 and 80 years old, have a body mass index (BMI) between 18 and 28, and be scheduled for an elective surgery that will require anesthesia lasting between 1 to 4 hours. However, people with certain health issues—like severe high blood pressure, recent heart problems, uncontrolled diabetes, or significant liver and kidney problems—will not be able to participate. If you or a loved one is considering joining this study, you can expect to receive carefully monitored anesthesia during your surgery and help researchers learn more about how to keep older patients safe during these procedures.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ASA Ⅰ\~Ⅲ;
• • BMI was 18-28 kg/m2;
• • For elective abdominal surgery under intravenous general anesthesia;
• • The expected duration of anesthesia was 1 to 4 hours.
• Exclusion Criteria:
• • Septic shock and multiple organ failure diagnosed within 14 days;
• • Hyperkalemia (serum potassium \>5.5mmol/L) within 48 hours;
• • Stroke or transient ischemic attack within 3 months;
• • Patients with unstable angina pectoris or myocardial infarction within 3 months; Arrhythmia requiring treatment was not treated or treatment did not meet expectations;
• • Patients with preoperative diagnosed diabetes mellitus and uncontrolled blood glucose; Diabetic complications were diagnosed before surgery, including diabetic ketoacidosis, hyperosmolar coma, diabetes-related infection, diabetic nephropathy, retinopathy, diabetic cardiomyopathy, diabetic neuropathy, diabetic foot, etc.
• • Severe liver and renal dysfunction;
• • Liver surgery, renal surgery, adrenal surgery, day surgery;
• • Resting blood pressure ≥180/110 mmHg (2020 ISH hypertension guideline ≥ grade 3 hypertension); Or systolic blood pressure \<90mmHg or mean blood pressure \<65mmHg.
• • Taking corticosteroids or other immunosuppressants for more than 10 days within 6 months or having a history of adrenal cortex suppression or immune system diseases;