NESA Neuromodulation Versus Transcutaneous Posterior Tibial Stimulation

Launched by DANIEL DAVID ÁLAMO ARCE · Jun 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two non-invasive treatments for overactive bladder (OAB), which is a condition that causes a sudden urge to urinate, often leading to frequent trips to the bathroom. The trial aims to compare NESA neuromodulation, a new treatment that helps regulate bladder control, with another method called transcutaneous posterior tibial stimulation. Both treatments will be accompanied by exercises and education to help improve the participants' quality of life, manage symptoms, and enhance their sleep.

To participate, individuals must be adult women aged 38 to 85 with a diagnosis of overactive bladder who have not found relief from previous treatments. Those interested will attend ten sessions over five weeks, during which their quality of life and symptoms will be assessed through questionnaires. Participants will receive detailed information about the trial and must provide written consent before joining. The study has been approved by an ethics committee, ensuring that it is conducted safely and responsibly.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Minimum criteria for a primary diagnosis of overactive bladder who have or have not received active/alternative treatments for this pathology.
• • Patients with previous pharmacological treatments that have not obtained an adequate clinical response.
• • Patients whose cognitive abilities are competent to participate in the study and are able to complete the study questionnaires and have given written consent to participate in the study.
• • Without further contraindications for electrotherapy treatment such as serious use of pacemakers, pregnancy, internal bleeding, poor skin condition (ulcerations, wounds...) and/or phobia of electricity.
• Exclusion Criteria:
• • Presence of urinary fistula.
• • Infections in the last 12 months.
• • Haematuria during the trial period.
• • Pregnancy or plans to become pregnant during the study.
• • Pathology of the central or peripheral nervous system (multiple sclerosis, Parkinson's disease, etc.).
• • Uncontrolled diabetes.
• • Currently treated with Botox injections for the bladder or within the last year.
• • Current treatment with interstim or currently implanted interstim device.
• • Bladder outlet obstruction.
• • Urinary retention.
• • Treatment with more than two antidepressants and/or multiple benzodiazepines, as well as antiepileptics.
• • Contraindications for electrotherapy treatment.